Evaluation of NPHS2 gene polymorphism (R229Q) in chronic kidney disease patients

Document Type : Original Article

Authors

1 Internal medicine department, Faculty of Medicine, Beni-Suef University, Egypt

2 Chemical and clinical pathology department, Faculty of Medicine, Beni-Suef University, Egypt

Abstract

The aim of this study was to evaluate the role of nephrotic syndrome 2 (NPHS2) gene polymorphism (R229Q) in chronic kidney disease which has unclear etiology.
This study was conducted on 80 CKD patients compared with 40 age and sex matched normal volunteers acting as a control group. All of them underwent renal function tests and were assessed for the presence of NPHS2 gene polymorphism. We noticed that (R229Q) is a common variant in Egyptian population. Its concentration was (62.5%) in CKD patients and (55%) in control group. There was no significant difference with p-value > 0.05 between patients and control groups as regards to NPHS2 genotypes and alleles.

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References

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