Vascular calcification is a major complication of End stage renal disease patient on hemodialysis. A cross sectional cohort study in Beni Suef university hospital for a group of patients with End stage renal disease on regular hemodialysis. In total, 70 participants were divided into the study (50 patients) and (20 control groups). group showed higher miR-126 levels compared with the control group. Carotid intimal medial thickness (CIMT) was positively correlated with miR- 126.
Amabile N, Guerin AP, Tedgui A, Boulanger CM, London GM. Predictive value of circulating endothelial microparticles for cardiovascular mortality in end-stage renal failure: a pilot study. Nephrol Dial Transplant. 2012; 27:1873–1880.
Braun J, Oldendorf M, Moshage W, Heidler R, Zeitler E, Luft FC: Electron beam computed tomography in the evaluation of cardiac calcification in chronic dialysis patients. Am J Kidney Dis 27 : 394 –401, 1996
Coresh J, Astor BC, Graene T, et al. Prevalence of chronic kidney disease and decreased kidney function in the adult US population. Third National Health and Nutrition Examination Survey. Am J Kidney Dis 2003;41:1-12.
Fish JE, Santoro MM, Morton SU, Yu S, Yeh RF, Wythe JD, et al. parathyroid hormone level regulates angiogenic signaling and vascular integrity. Dev Cell. 2008; 15:272–284.
Salusky IB: Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med 342 : 1478 –1483, 2000
.Levin A. Clinical epidemiology of cardiovascular disease in chronic kidney disease prior to dialysis. Semin Dial. 2003; 16:101–105.
Mitchell PS, Parkin RK, Kroh EM, Fritz BR, Wyman SK, Pogosova-Agadjanyan EL, et al. Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A. 2008; 105:10513–10518
Mitterbauer C, Schwarz C, and Haas M, Oberbauer R: Effects of bisphosphonates on bone loss in the first year after renal transplantation: A meta-analysis of randomized controlled trials. Nephrol Dial Transplant 21 : 2275 –2281, 2006
Moe SM, O’Neill KD, Duan D, Ahmed S, Chen NX, Leapman SB, Fineberg N, Kopecky K: Medial artery calcification in ESRD patients is associated with deposition of bone matrix proteins. Kidney Int 61 : 638 –647,2002
National Kidney Foundation. Kidney Disease. New York, NY: National Kidney Foundation:2008
Naves M, Guinsburg A, Marelli C, Tejada J, Silvestri F, Passlick-Deetjen J, Cannata- Andia J: Relative risk (RR) of death according to serum Ca, P and PTH. Results from a large sample of dialysis patients from Latin America followed for up to 54 months. The CORES Study J Am Soc Nephrol 16 : 728A , 2005
Neal CS, Michael MZ, Pimlott LK, Yong TY, Li JY, Gleadle JM. Circulating microRNA expression is increased in chronic kidney disease. Nephrol Dial Transplant. 2011; 26:3794–3802.
O’Hare AM, Choi AI, Bertenthal D. Age affects outcomes in chronic kidney disease. J Am Soc Nephrol 2007; 18:2758 2765.
Price PA, Faus SA, Williamson MK: Bisphosphonates alendronate and ibandronate inhibit artery calcification at doses comparable to those that inhibit bone resorption. Arterioscler Thromb Vasc Biol 21 : 817 –824, 2001
Prokopi M, Pula G, Mayr U, Devue C, Gallagher J, Xiao Q, et al. Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures. Blood. 2009; 114:723– 732.
Schafer C, Heiss A, Schwarz A, Westenfeld R, Ketteler M, Floege J, Muller-Esterl W, Schinke T, Jahnen- Dechent W: The serum protein alpha 2- Heremans-Schmid glycoprotein/fetuin-A is a systemically acting inhibitor of ectopic calcification. J Clin Invest 112 : 357 –366, 2003
Schlondorff DO. Overview of factors contributing to the pathophysiology of progressive renal disease. Kidney Int 2008; 74:860-866.
Sequeira Lopez ML, Gomez RA. Novel mechanisms for the control of renin synthesis and release. Curr Hypertens Rep. 2010; 12:26–32.
Xiaoying jiang , Eleni Tsitsiou ,and mark A Lindsay /microRna and the regulation of fibrosis 2019
Zernecke A, Bidzhekov K, Noels H, Shagdarsuren E, Gan L, Denecke B, et al. Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection. Sci Signal. 2009; 2:ra81.
Zhang Q, Kandic I, Kutryk MJ. Dysregulation of angiogenesis-related microRNAs in endothelial progenitor cells from patients with coronary artery disease. Biochem Biophys Res Commun. 2011; 405:42–46.
Ata Rofaiel Bebawi, K., Hamdy Mahmoud, H., & Sayed Abd Elbasset, A. (2021). Study Of Circulating Levels Of Mir-126 And Vascular Complication In End Stage Renal Disease Patients On Heamodialysis. Egyptian Journal of Medical Research, 2(2), 75-87. doi: 10.21608/ejmr.2021.174611
MLA
Keroles Ata Rofaiel Bebawi; Heba Hamdy Mahmoud; Ahmed Sayed Abd Elbasset. "Study Of Circulating Levels Of Mir-126 And Vascular Complication In End Stage Renal Disease Patients On Heamodialysis", Egyptian Journal of Medical Research, 2, 2, 2021, 75-87. doi: 10.21608/ejmr.2021.174611
HARVARD
Ata Rofaiel Bebawi, K., Hamdy Mahmoud, H., Sayed Abd Elbasset, A. (2021). 'Study Of Circulating Levels Of Mir-126 And Vascular Complication In End Stage Renal Disease Patients On Heamodialysis', Egyptian Journal of Medical Research, 2(2), pp. 75-87. doi: 10.21608/ejmr.2021.174611
VANCOUVER
Ata Rofaiel Bebawi, K., Hamdy Mahmoud, H., Sayed Abd Elbasset, A. Study Of Circulating Levels Of Mir-126 And Vascular Complication In End Stage Renal Disease Patients On Heamodialysis. Egyptian Journal of Medical Research, 2021; 2(2): 75-87. doi: 10.21608/ejmr.2021.174611