Evaluation of serum levels of CD14 in neonatal sepsis and its correlation with type of infection in Beni-Suef University Hospital

Document Type : Original Article

Authors

1 Medical Microbiology and Immunology department, Faculty of Medicine, Beni-Suef University, Egypt

2 Pediatrics department, Faculty of Medicine, Beni-Suef University, Egypt

Abstract

The aim of the present study was to identify the incidence of sepsis among neonates admitted at Beni-Suef University Hospital during the period of the study, to identify different organisms responsible for sepsis and the serum level of CD14 (presepsin) was investigated as a biomarker of sepsis. All neonates suspected with sepsis during the time of the study admitted in neonatal intensive care unit at Beni-Suef University Hospital were screened for sepsis by blood culture and presepsin levels were investigated. The incidence of sepsis was 32.4%. Presepsin marker had a significant role in prediction of presence of sepsis, at a cut off value of 2300 or more of presepsin, it can predict the presence of sepsis with sensitivity of (94.29%), specificity of (88.6%), positive predictive value (89.2%) and negative predictive value (93.9%)

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References

  1. Kumar, A. (2014). An alternate pathophysiologic paradigm of sepsis and septic shock: implications for optimizing antimicrobial therapy. Virulence, 5(1), 80-97.
  2. Greenberg, R. G., Kandefer, S., Do, B. T., Smith, P. B., Stoll, B. J., Bell, E. F Van Meurs, K. P. (2017). Late-onset sepsis in extremely premature infants: 2000–2011. The Pediatric infectious disease journal, 36(8), 774.
  3. Sa’adu, L. O., Obasa, T. O., Saka, A. O., Saka, M. J, Nwabuisi, C. (2019). Multi-drug resistance in early and late onset neonatal sepsis in a tertiary hospital in Nigeria. Annals of African Medical Research, 2.
  4. Ganatra, H. A., Stoll, B. J., Zaidi, A. K. (2010). International perspective on early-onset neonatal sepsis. Clinics in perinatology, 37(2), 501-523.
  5. Mayuga, W. A. B., Isleta, P. F. D. (2005). Clinical correlation of neonatal and maternal hematological parameters as predictors of neonatal sepsis. PIDSP J, 9 (2), 36-42.
  6. Cortese, F., Scicchitano, P., Gesualdo, M., Filaninno, A., De Giorgi, E., Schettini, F., ... & Ciccone, M. M. (2016). Early and late infections in newborns: where do we stand? A review. Pediatrics & Neonatology, 57(4), 265-273.
  7. Mahmoud Zayed, K., Abd ELmoez Ali Saad, A., Mohamed Amin, W., & Gamal Abo El-Nasr, M. (2020). Diagnostic value of presepsin in detection of early- onset neonatal sepsis. Al-Azhar Journal of Pediatrics, 23(2), 825-851.
  8. Singel, H. (2021). Correlation of C-reactive protein and Blood Culture in Neonatal Sepsis in A Tertiary Health Care Centre, Bhavnagar. Saudi J Pathol Microbiol, 6 (2), 56-57.
  9. Dorum, B. A., Özkan, H., Çakir, S. Ç., Köksal, N., Gözal, Z., Çelebi, S., & Hacimustafoğlu, M. (2021). The diagnostic value of serum amyloid A in early-onset neonatal sepsis in premature infants. HK J Paediatr (new series), 26(1), 2021.
  10. Glaser, M. A, Hughes, L. M., Jnah, A., Newberry, D., & Harris-Haman, P. A. (2021). Neonatal Sepsis: A Review of Pathophysiology and Current Management Strategies. Advances in Neonatal Care, 21(1), 49-60.
  11. Lamichhane, A., & Mishra, A. (2019). Correlation between C-Reactive Protein and Blood Culture in Neonatal Sepsis at a Tertiary Care Centre in Western Nepal. Journal of Lumbini Medical College, 7(2), 88-92.
  12. Hamam, S. M., Shimaa, M., Hamed, M., & Mohamed, S. (2019). Incidence of Neonatal Sepsis and the Causative Organisms in Neonatal Intensive Care Unit of Tanta University Hospital. The Medical Journal of Cairo University, 87(December), 5323-5332.
  13. Medhat, H., & Khashana, A. (2017). Incidence of neonatal infection in South Sinai, Egypt. International Journal of Infection, 4(1).
  14. Abdellatif, M., Al-Khabori, M., Rahman, A. U., Khan, A. A., Al-Farsi, A., & Ali, K. (2019). Outcome of Late-onset Neonatal Sepsis at a Tertiary Hospital in Oman. Oman medical journal, 34(4), 302.
  15. Lakhey, A., & Shakya, H. (2017). Role of sepsis screening in early diagnosis of neonatal sepsis. Journal of Pathology of Nepal, 7(1), 1103-1110.20- Knapp RG, Miller MC. Clinical epidemiology and biostatistics. Published by Williams &​ Wilkins; Malvern, Pa. : Harwal Pub. Co., C.
  16. Kayiga, H., Lester, F., Amuge, P. M., Byamugisha, J., & Autry, A. M. (2018). Impact of mode of delivery on pregnancy outcomes in women with premature rupture of membranes after 28 weeks of gestation in a low-resource setting: A prospective cohort study. PloS one, 13(1), e0190388.
  17. Adatara, P., Afaya, A., Salia, S. M., Afaya, R. A., Konlan, K. D., Agyabeng-Fandoh, E., ... & Boahene, I. G. (2019). Risk factors associated with neonatal sepsis: a case study at a specialist hospital in Ghana. The Scientific World Journal.
  18. Awad, H. M. A. E. M., Hawary, M. B. E. A., Kholef, E. F. M., & Ali, M. A. R. A. (2020). Serum Neopterin Level in Early Onset Neonatal Sepsis. The Egyptian Journal of Hospital Medicine, 81(1), 1193-1203.
  19. Al-Mayah, Q. S., Chalob, F. A., & Jawad, T. I. (2017). Incidence of neonatal sepsis in a sample of Iraqi newborns. Pak J Biotechnol, 14(4), 797-802.
  20. Reddy, K. V., Sailaja, K., Ashok, A., & Poojitha, K. (2017). Clinico-bacteriological Profile of neonatal sepsis in rural Tertiary Care Hospital. International Journal of Contemporary Pediatrics, 4(4), 1259-1262.
  21. Shehab El-Din, E. M. R., El-Sokkary, M. M. A., Bassiouny, M. R., & Hassan, R. (2015). Epidemiology of neonatal sepsis and implicated pathogens: a study from Egypt. BioMed research international, 2015.
  22. Atif, M., Zia, R., Malik, I., Ahmad, N., & Sarwar, S. (2021). Treatment outcomes, antibiotic use and its resistance pattern among neonatal sepsis patients attending Bahawal Victoria Hospital, Pakistan. PloS one, 16(1), e0244866
  23. 23- Kumari, M., Dash, R. K., Kishore, B., & Srikant, A. (2021). Aetiological profile, risk factors, antibiotic sensitivity pattern and outcome of neonatal sepsis in tertiary care hospitals-a prospective observational study. European Journal of Molecular & Clinical Medicine, 8(02), 2021.
  24. Fahmey SS. (2013): “Early-onset sepsis in a neonatal intensive care unit in beni suef, Egypt: bacterial isolates and antibiotic resistance pattern,” Korean Journal of Pediatrics, vol. 56, no. 8, pp. 332–337.
  25. Umemura, Y., Ogura, H., Takuma, K., Fujishima, S., Abe, T., Kushimoto, S., ... & Gando, S. (2021). Current spectrum of causative pathogens in sepsis: A prospective nationwide cohort study in Japan. International Journal of Infectious Diseases, 103, 343-351.
  26. Osman, A. S., Awadallah, M. G., Tabl, H. A. E. M., Abed, N. T., & Goudah, E. S. S. (2015). Presepsin as a novel diagnostic marker in neonatal septicemia. The Egyptian Journal of Medical Microbiology (EJMM), 24(3).
  27. Yunanto A, Margareta Y, Indah D, Pratiwi N. (2014): American Journal of Oral Medicine and Radiology Bacteriological Pattern And Antibiotic Susceptibility In Neonatology Ward Ulin General Hospital, Banjarmasin, Indonesia. 2014;1(1):10–13.
  28. Khater, E. S., & Al-Hosiny, T. M. (2020). Presepsin as a New Marker for Early Detection Neonatal Sepsis in Al-Quwayiyah General Hospital Riyadh, KSA. Journal of Advances in Microbiology, 80-90.
  29. Ozdemir, A. A., & Elgormus, Y. (2017). Diagnostic value of presepsin in detection of early-onset neonatal sepsis. American journal of perinatology, 34(06), 550-556.
  30. Kumar, N., Dayal, R., Singh, P., Pathak, S., Pooniya, V., Goyal, A., ... & Mohanty, K. K. (2019). A comparative evaluation of presepsin with procalcitonin and CRP in diagnosing neonatal sepsis. The Indian Journal of Pediatrics, 86(2), 177-179.
  31. Zou, Q., Wen, W., & Zhang, X. C. (2014). Presepsin as a novel sepsis biomarker. World journal of emergency medicine, 5(1), 16.

 

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