Detection of Cyclophilin D in Psoriasis and its Correlation with Disease Severity

Document Type : Original Article

Authors

1 Dermatology department,Faculty of Medicine, Beni-Suef University,Egypt

2 Biochemistry department,Faculty of Medicine, Cairo University, Egypt

Abstract

The aim of the work to detect the level of Cyclophilin-D in psoriasis and its correlation with disease severity. Samples included 84 persons divided into 2 groups (42) patients having psoriasis and (42) apparently healthy age and sex-matched individuals. All individuals included in the study were subjected to full history, full clinical examination, 3 cm of blood had been taken from patients of psoriasis and matched controls and centrifuged for serum separation which kept frozen at -80c till analysis of Cyclophilin-D by ELISA technique.

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References

  1.  Basseri S, Austin RC. (2012):   Endoplasmic Reticulum Stress and Lipid Metabolism: Mechanisms and Therapeutic Potential. Biochem Res. Int 841362.
  2. Basseri, S., & Austin, R. C. (2012). Endoplasmic reticulum stress and lipid metabolism: mechanisms and therapeutic potential. Biochemistry research international, 2012.‏
  3. Hotamisligil GS (2010): Endoplasmatic reticulum stress and the inflammatory basis of metabolic disease. Cell 140: 900-917.
  4. Hotamisligil, G. S. (2010). Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell, 140(6), 900-917.‏
  5. Bernardi, P., Vassanelli, S., Veronese, P., Colonna, R., Szabo, I., & Zoratti, M. (1992). Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations. Journal of Biological Chemistry, 267(5), 2934-2939.‏
  6. LeMone, P., Burke, K., Dwyer, T., Levett-Jones, T., Moxham, L., & Reid-Searl, K. (2015). Medical-surgical nursing. Pearson Higher Education AU.‏
  7. Kreft, S., Kreft, M., Resman, A., Marko, P., & Kreft, K. Z. (2006). Computer-aided measurement of psoriatic lesion area in a multicenter clinical trial—Comparison to physician's estimations. Journal of dermatological science, 44(1), 21-27.‏
  8. Stamnes, M. A., Rutherford, S. L., & Zuker, C. S. (1992). Cyclophilins: a new family of proteins involved in intracellular folding. Trends in cell biology, 2(9), 272-276.‏
  9. Bernardi, P., Vassanelli, S., Veronese, P., Colonna, R., Szabo, I., & Zoratti, M. (1992). Modulation of the mitochondrial permeability transition pore. Effect of protons and divalent cations. Journal of Biological Chemistry, 267(5), 2934-2939.‏
  10. Basso, E., Fante, L., Fowlkes, J., Petronilli, V., Forte, M. A., & Bernardi, P. (2005). Properties of the permeability transition pore in mitochondria devoid of Cyclophilin D. Journal of Biological Chemistry, 280(19), 18558-18561
  11. Doczi, J., Turiák, L., Vajda, S., Mándi, M., Töröcsik, B., Gerencser, A. A., ... & Chinopoulos, C. (2011). Complex contribution of cyclophilin D to Ca2+-induced permeability transition in brain mitochondria, with relation to the bioenergetic state. Journal of Biological Chemistry, 286(8), 6345-6353.‏
  12. Nigro, P., Pompilio, G., & Capogrossi, M. C. (2013). Cyclophilin A: a key player for human disease. Cell death & disease, 4(10), e888.‏
  13. Griffiths, C. E. M., Van der Walt, J. M., Ashcroft, D. M., Flohr, C., Naldi, L., Nijsten, T., & Augustin, M. (2017). The global state of psoriasis disease epidemiology: a workshop report. British Journal of Dermatology, 177(1), e4-e7.
  14. Liang, Y., Sarkar, M. K., Tsoi, L. C., & Gudjonsson, J. E. (2017). Psoriasis: a mixed autoimmune and autoinflammatory disease. Current opinion in immunology, 49, 1-8.‏
  15. Calautti, E., Avalle, L., & Poli, V. (2018). Psoriasis: a STAT3-centric view. International journal of molecular sciences, 19(1), 171.‏
  16. Fiorino, G., Allez, M., Malesci, A., & Danese, S. (2009). anti TNF‐α induced psoriasis in patients with inflammatory bowel disease. Alimentary pharmacology & therapeutics, 29(9), 921-927.‏
  17. Ogawa, E., Sato, Y., Minagawa, A., & Okuyama, R. (2018). Pathogenesis of psoriasis and development of treatment. The Journal of dermatology, 45(3), 264-272.‏
  18. Chamcheu, J. C., Pal, H. C., Siddiqui, I. A., Adhami, V. M., Ayehunie, S., Boylan, B. T., ... & Wood, G. S. (2015). Prodifferentiation, anti-inflammatory and antiproliferative effects of delphinidin, a dietary anthocyanidin, in a full-thickness three-dimensional reconstituted human skin model of psoriasis. Skin pharmacology and physiology, 28(4), 177-188
  19. Johar, A., Sarmiento-Monroy, J. C., Rojas-Villarraga, A., Silva-Lara, M. F., Patel, H. R., Mantilla, R. D., ... & Anaya, J. M. (2016). Definition of mutations in polyautoimmunity. Journal of autoimmunity, 72, 65-72.‏
  20. Kumari, S., & Pasparakis, M. (2015). Epithelial cell death and inflammation in skin. In Apoptotic and Non-apoptotic Cell Death (pp. 77-93). Springer, Cham.‏
  21. Hagforsen, E., Lampinen, M., Paivandy, A., Weström, S., Velin, H., Öberg, S., ... & Rollman, O. (2017). Siramesine causes preferential apoptosis of mast cells in skin biopsies from psoriatic lesions. British Journal of Dermatology, 177(1), 179-187.‏
  22. Hong, F., Lee, J., Song, J. W., Lee, S. J., Ahn, H., Cho, J. J., ... & Kim, S. S. (2002). Cyclosporin A blocks muscle differentiation by inducing oxidative stress and inhibiting the peptidyl-prolyl-cis-trans isomerase activity of cyclophilin A: cyclophilin A protects myoblasts from cyclosporin A-induced cytotoxicity. The FASEB Journal, 16(12), 1633-1635.‏
  23. Choi, K. J., Piao, Y. J., Lim, M. J., Kim, J. H., Ha, J., Choe, W., & Kim, S. S. (2007). Overexpressed cyclophilin A in cancer cells renders resistance to hypoxia-and cisplatin-induced cell death. Cancer research, 67(8), 3654-3662.‏
  24. Lin, D. T., & Lechleiter, J. D. (2002). Mitochondrial targeted cyclophilin D protects cells from cell death by peptidyl prolyl isomerization. Journal of Biological Chemistry, 277(34), 31134-31141.‏
  25. Schinzel, A. C., Takeuchi, O., Huang, Z., Fisher, J. K., Zhou, Z., Rubens, J., ... & Korsmeyer, S. J. (2005). Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia. Proceedings of the National Academy of Sciences, 102(34), 12005-12010.‏
  26. Baines, C. P., Kaiser, R. A., Purcell, N. H., Blair, N. S., Osinska, H., Hambleton, M. A., ... & Robbins, J. (2005). Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature, 434(7033), 658.‏
  27. Slominski, A. T., Zmijewski, M. A., Semak, I., Kim, T. K., Janjetovic, Z., Slominski, R. M., & Zmijewski, J. W. (2017). Melatonin, mitochondria, and the skin. Cellular and molecular life sciences, 74(21), 3913-3925.‏
  28. Porter, G. A., & Beutner, G. (2018). Cyclophilin D, Somehow a master regulator of mitochondrial function. Biomolecules, 8(4), 176.‏
  29. López-Estebaranz, J. L., Sánchez-Carazo, J. L., & Sulleiro, S. (2016). Effect of a family history of psoriasis and age on comorbidities and quality of life in patients with moderate to severe psoriasis: Results from the ARIZONA study. The Journal of dermatology, 43(4), 395-401.
  30. Griffiths, C. E., Fisher, G. J., Harding, M. W., Elder, J. T., & Voorhees, J. J. (1990). Cyclophilin content of normal and psoriatic epidermis. Journal of investigative dermatology, 94(4), 436-440.‏

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