The goal of this study is to measure serum level of I Kappa B in patients with psoriasis in comparison with healthy controls. 50 psoriatic patients and 40 age & gender matched apparently healthy controls were included in the study, patients were classified according to Psoriasis Area & Surface Index (PASI) score and serum samples for all participants were taken to measure I Kappa B level for each. The level of serum I Kappa B was found to be significantly lower in the patients (3.96 ±1.96) than in controls (11.02 ±2.22). This difference was of statistical significance (p-value =0.001).
Krueger JG and Lowes MA. (2015). (Effective narrow-band UVB radiation therapy suppresses the IL-23/IL-17 axis in normalized psoriasis plaques). J Invest Dermatol. 130(11):2654-63.
Milčić D, Janković S, Vesić S, Milinković M, Marinković J, Ćirković A and Janković J.(2017).( Prevalence of metabolic syndrome in patients with psoriasis: a hospital-based cross-sectional study).
Tupikowska-Marzec M, Kolačkov K , Zdrojowy-Wełna A, Słoka NK, Szepietowski JC and Maj J.(2019). ( The Influence of FTO Polymorphism rs9939609 on Obesity, Some Clinical Features, and Disturbance of Carbohydrate Metabolism in Patients with Psoriasis). Biomed Res Int.73 (45):43_45.
Laura C, Laura S and Paul E. (2016). (psoriasis pathogenesis).Hand Book of Psoriasis and Psoriatic Arthritis; 1: 7-16.
Huxford T, Hoffmann A and Ghosh G. (2011). (Understanding the logic of IκB:NF-κB regulation in structural terms). Curr Top Microbiol Immunol .349:1–24.
Lin AM, Rubin CJ and Khandpur R. (2011). ( Mast cells and neutrophils release IL-17 through extracellular trap formation inpsoriasis). J Immunol . 187:490–500.
Doger FK, Dikicioglu E and Ergin F.(2007). ( Nature of cell kinetics in psoriatic epidermis). J Cutan Pathol .34: 257–263.
Knapp RG, Miller MC. Clinical epidemiology and biostatistics. Published by Williams & Wilkins; Malvern, Pa. : Harwal Pub. Co., C.
Marten Beck, Krestin M, Peter G and Jorge lamboy .(2016). (Binding of NF-KB appears to twist The Ankyrin Repeat Domain of IKB). Biophysical journal.10:887-895.
Mathes E, Wang L, Komives E and Ghosh G. (2010). (Flexible regions within IκBα create the ubiquitin-independent degradation signal). J Biol Chem 285(43):32927–32936.
Savinova OV, Hoffmann A and Ghosh G. (2009). (The Nfkb1 and Nfkb2 proteins p105 and p100 function as the core of high-molecular-weight heterogeneous complexes). Mol Cell. 34(5):591–602.
Bergqvist S, Alverdi V, Mengel B, Hoffmann A, Ghosh G and Komives EA. (2009). (Kinetic enhancement of NF-κB:DNA dissociation by IκBα). Proc Natl Acad Sci USA. 106(46):19328–19333.
Wilson NJ. (2007). (Development, cytokine profile and function of human interleukin 17-producing helper T cells). Nat Immunol. 8(9):950–957.
Sano S. (2005). (Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model). Nat Med 11(1):43–49.
Hayden MS and Ghosh S. (2012). (NF‐kappaB, the first quarter‐century: remarkable progress and outstanding questions). Genes Dev 26, 203–234.
Lin AM, Rubin CJ and Khandpur R. (2011). ( Mast cells and neutrophils release IL-17 through extracellular trap formation inpsoriasis). J Immunol . 187:490–500.
Goldminz AM, Au SC and Kim N. (2013). (NF-κB: an essential transcription factor in psoriasis). J Dermatol Sci. 69:89–94.
Totzke G, et al. (2006). (A novel member of the IkappaB family, human IkappaB-zeta, inhibits transactivation of p65 and its DNA binding). J Biol Chem. 281:12645–12654.
Trinh DV, Zhu N, Farhang G, Kim BJ and Huxford T. (2008). (The nuclear IκB protein IκBζ specifically binds NF-κB p50 homodimers and forms a ternary complex on κB DNA). J Mol Biol. 379(1):122–135.
Muromoto R, Hirao T, Tawa K, Hirashima K, Kon S and Kitai Y.(2016). (IL-17A plays a central role in the expression of psoriasis signature genes through the induction of IκB-ζ in keratinocytes). Int Immunol. 28(9):443–52.
Johansen C, Mose M, Ommen P, Bertelsen T, Vinter H, Hailfinger S, Lorscheid S, Schulze-Osthoff K and Iversen L. (2015). (IκBζ is a key driver in the development of psoriasis). Proc Natl Acad Sci U S A. 112(43):E5825-33.
Claus Johansen, Maike Mose, Pernille Ommen, Trine Bertelsen, Hanne Vinter and Stephan Hailfinger. (2015). (IκBζ is a key driver in the development of psoriasis). PNAS.112(20):122-142.
Abdelazeem, N., El Refaiee, A., & Othman, S. (2022). I-KappaB Expression in Patient with Psoriasis Vulgaris. Egyptian Journal of Medical Research, 3(2), 7-22. doi: 10.21608/ejmr.2022.231672
MLA
Nahed Omar Abdelazeem; Abdelaziz Abdel Salam El Refaiee; Shimaa Taha Othman. "I-KappaB Expression in Patient with Psoriasis Vulgaris", Egyptian Journal of Medical Research, 3, 2, 2022, 7-22. doi: 10.21608/ejmr.2022.231672
HARVARD
Abdelazeem, N., El Refaiee, A., Othman, S. (2022). 'I-KappaB Expression in Patient with Psoriasis Vulgaris', Egyptian Journal of Medical Research, 3(2), pp. 7-22. doi: 10.21608/ejmr.2022.231672
VANCOUVER
Abdelazeem, N., El Refaiee, A., Othman, S. I-KappaB Expression in Patient with Psoriasis Vulgaris. Egyptian Journal of Medical Research, 2022; 3(2): 7-22. doi: 10.21608/ejmr.2022.231672