Prevalence of hypocalcemia in asymptomatic pregnant females in Upper Egypt

Document Type : Original Article

Authors

1 Obstetrics and Gynecology department, Faculty of Medicine, Beni-Suef University, Egypt

2 Obstetrics and Gynecology department, Faculty of Medicine, Cairo University, Egypt

Abstract

The goal of this study is to investigate the levels of serum calcium in asymptomatic pregnant women and measuring the prevalence of hypocalcaemia. Healthy pregnant women (n=500) were enrolled consecutively, with singleton pregnancy, in first trimester with the mean gestational age (9.5 ±1) weeks of gestation. Serum Total and Ionized calcium were measured to all women in the study. The prevalence of hypocalcaemia was measured. Nearly two thirds of women (337) had hypocalcaemia (67.4%), Only 163 had normal calcium levels" serum calcium level of 8.6 mg/dL or above". The prevalence of hypocalcaemia was more in young aged women as about two-thirds (64.8%) were in the age group 20 to less than 30 years, with mean age 23.9 ±4.6 years. Also the prevalence of hypocalcaemia was high in parity less than 2, with statistically significant p-value (0.034). No determinants (education, dietary intake of Ca+2, weight, height, BMI, and Hb levels) found in our study to be in correlation with the high incidence of hypocalcaemia.

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References

  1. Peacock M ,Clin J Am SocNephrol. (2010): Calcium metabolism in health and disease. 2010 Jan;5(Suppl 1):S23-S30.
  2. Pu F, Chen N and Xue S. (2016): Calcium intake, calcium homeostasis and health. Food Science and Human Wellness; 5(1):8-16.
  3. Ross AC, Taylor CL, Yaktine AL and et al. (2011): Institute of Medicine (US) Committee to Review Dietary Reference Intakes for Vitamin D and Calcium.
  4. Blaine J, Chonchol M, Levi M (2015):"Renal control of calcium, phosphate, and magnesium homeostasis". Clinical Journal of the American Society of Nephrology. 10 (7): 1257–72. doi:10.2215/CJN.09750913.
  5. Kumar A, Agarwal K, Devi SG, Gupta RK and Batra S. (2010): Hypocalcemia in pregnant women. Biol Trace Elem Res;136:26-32.
  6. Watts NB.(2013):Estrogens, Estrogen agonists/antagonists, and calcitonin. In Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8th Edition, Rosen CJ (ed); Chapter 48, pp. 408-411.
  7. Murphy E, Williams GR. (2009): HypocalcaemiaMedicine; 37(9):465-8.
  8. Carroll R. and Matfin G. (2010): Endocrine and metabolic emergencies: hypocalcaemia. Therapeutic advances in endocrinology and metabolism, 1(1), 29–33. doi:10.1177/2042018810366494.
  9. Rhoades R (2009): Medical Physiology: Principles for Clinical Medicine. Philadelphia: Lippincott Williams & Wilkins. ISBN 978-0-7817-6852-8.
  10. Ajong A. B., Kenfack B., Ali I. M., Yakum M. N. and Telefo P. B. (2019):Prevalence and correlates of low serum calcium in late pregnancy: A cross sectional study in the Nkongsamba Regional Hospital; Littoral Region of Cameroon. PloS one, 14(11), e0224855. doi:10.1371/journal.pone.0224855.
  11. Institute of Medicine (2011): Committee to Review Dietary Reference Intakes for Vitamin D and Calcium. Dietary Reference Intakes for Calcium and Vitamin D. Washington, DC: National Academies Press; 2011.
  12. Benali A and Demmouche A. (2014): Calcium deficiency among pregnant women and their newborns in SidiBel Abbes Region, Algeria. J Nutr Food Sci;4:6.
  13. Akhtar S, Begum S andFerdousi S. (2011): Calcium and Zinc Deficiency in Pre-eclamptic Women. J BangldeshSocPhysiol;6(2):94–9.
  14. Sadaf S, Amna J, Fareeha R, Faseeha R and Ahmad J. (2017):Frequency of hypocalcemia in women with preeclampsia at a tertiary care hospital. Pakis J Med Heal Sci;11(2):773-776.
  15. Deepa V. Kanagal, Aparna R. and Kavyarashmi R. (2014): A study from coastal India: Levels of serum calcium and magnesium in pre-eclamptic and normal pregnancy. J ClinDiagn Res. Jul; 8(7).
  16. Hofmeyr GJ, Lawrie TA, Atallah ÁN, Duley L and Torloni MR. (2014): Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems. Cochrane Database Syst Rev 2014 Jun ;(6):CD001059 .
  17. Scholl TO, Chen X and Stein TP. (2014): Maternal calcium metabolic stress and fetal growth. Am J ClinNutr 2014 Apr;99(4):918- 925.
  18. Vafaei H, Dalili M andHashemi SA. (2015):Serum concentration of calcium, magnesium and zinc in normotensive versus preeclampsia pregnant women: A descriptive study in women of Kerman province of Iran. Iran J Reprod Med; 13:23±6. PMID: 25653672
  19. Ugwuja, Emmanuel &Famurewa, Ademola&Ikaraoha, Ikechukwu. (2016): Comparison of Serum Calcium and Magnesium BetweenPreeclamptic and Normotensive Pregnant Nigerian Women in Abakaliki, Nigeria. Annals of Medical and Health Sciences Research. 6. 33-37. 10.4103/2141-9248.180269

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