Circular Ribonucleic Acid Expression in Patient with Acne

Document Type : Original Article

Authors

1 Dermatology and Andrology Department, Faculty of Medicine, benha university

2 Dermatology and Andrology Department, Faculty of Medicine, beni-suef university

3 Dermatology. Faculty of benj souif

Abstract

Background: Acne is a common chronic skin disease with a multifactorial aetiology and pathogenesis. Recently, circular RNAs (circRNAs) have been identified as a key factor in regulating gene expression through circRNA–miRNA–mRNA networks in many biological processes and human diseases. However, the circRNAs expression in patients with acne is still unknown, Aim and Objectives: To evaluate circular RNA Expression in Patient with Acne and to correlate its level with acne severity, Subjects and Methods: this was a case control study was conducted at conducted at Dermatology outpatient clinic at Beni-Suef University hospital including 40 with acne vulgaris and 40 normal as control. The duration of the study ranged from 6 months, Results: The mean CIRCULAR RNA 0001073 for cases group was 0.47 (±0.3 SD) with range (0.11-1.2) and that the mean CIRCULAR RNA 0001073 for control group was 1.03 (±0.1 SD) with range (0.95-1.2), and There was high statistically significant difference between the studied groups as regard CIRCULAR RNA 0001073. Conclusion: This study firstly showed that circRNAs were differentially expressed in severe acne and suggested that circRNAs could be used as a potential biomarker for the drug targets of acne.

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Egyptian Journal of Medical Research
Volume 3, Issue 4
October 2022
Pages 209-227

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