Comparison of Ranibizumab alone versus Ranibizumab with Targeted Retinal Laser for Branch Retinal Vein Occlusion with Macular Oedema.

Abdelmoneem, Mohamed Gamal; Sayed Saif, Mohamed Yasser; Abd Elkalek, Mohamed Othman

doi:10.21608/ejmr.2021.98694.1142

Comparison of Ranibizumab alone versus Ranibizumab with Targeted Retinal Laser for Branch Retinal Vein Occlusion with Macular Oedema.

Document Type : Original Article

Authors

¹ Ophthalmology department, Faculty of medicine, Beni Suef University.

² Ophthalmology department, Faculty of medicine, Beni-suef University

³ Ophthalmology department,Faculty of medicine, Beni-suef University

10.21608/ejmr.2021.98694.1142

Abstract

Background: Retinal vein occlusion is the second most common retinal vascular disease after diabetic retinopathy. Branch retinal venous occlusion (BRVO) occurs the occlusion of one of the branches of the retinal vein. The occlusion occurs mostly at arteriovenous crossing and more frequent in upper temporal retinal veins. Patients and Methods: In the current study, randomized control study was conducted on 2 groups divided into 27 eyes (Ranibizumab alone), 27 eyes (Ranibizumab and Targeted retinal laser). Results: The BRVO is investigated by FFA and OCT-Macula and macular edema is measured by OCT-Macula. And the current result shows highly statistically significant improvement in visual acuity and reducing macular edema (decrease foveal thickness)with P value <0.001 in Ranibizumab alone compared with Ranibizumab and retinal laser.

Keywords

Main Subjects

Surgery ·

References

Noma H, Minamoto A, Funatsu H, Tsukamoto H, Pathogenesis of macular Edema with branch retinal vein occlusion and intra ocular levels of vascular endothelial Growth factor and inter leukin -6, Am J Ophthalmol 2005:140:256-261.
Ravinder A, Susan B, Matthew D, Frederick L, Ronald Klein, anne S, Roy C, Rober D. The Eye disease case study, Am J Ophthalmolol.1993:116(3): 286-96.
Noma H, Minamoto A, Funatsu H, Tsukamoto H, Nakano K, Yamashita H, Intravitreal levels of vascular endothelial growth factor and interleukin-6 are correlated With macular edema in branch retinal vein occlusion, Graefes Arch Clin Exp With macular edema in branch retinal vein occlusion, Graefes Arch Clin Exp Ophthalmol 2006:244:309-1.
Campochiaro PA, Heier JS, Feiner L, Gray S, Saroj N, Rundle AC, Ranibizumab For macular edema following branch retinal vein occlusion: six month primary end Point results of a phase III study. Ophthalmology 2010: 117:1102-12.
Krohne TU, Liu Z, Holz FG, Meyer CH,. Intra ocular pharmacokinetics of ranibizumab Following a single intravitreal injection in humans, Am J ophthalmol 2012:154:682-6.e2.
Wessel MM, Aaker GD, Parlitsis G, Cho M, D Amico DJ, Kiss S, Ultra-wide-field Angiography improves the detectionand classification of diabetic retinopathy, Retina Phila Pa2012:32:789-91.
Karagiannis DA, Karampelas MD, Soumplis VM, et al, Recurrence of macular edema in Retinal vein occlusions after treatment with intravitreal ranibizumab (Lucentis),Can J Ophthalmol 2011: 46:486-490.
The Branch Vein Occlusion Study Group Argon laser photocoagulation for macular Edema in branch vein occlusion, Am Ophthalmol. 1984:98:271-282.
Ishiko S, Ogasawara H, Yoshida A, Hanada K, The use of scanning laser ophthalmoscope micro perimetry to detect visual impairment caused by macular Photocoagulation, Ophthalmic Surg Lasers 1998:29:95-98.
Campochiaro PA, Hafiz G, Mir TA, Scott AW, Solomon S, Zimmer Galler I, et al, Scatter Photocoagulation Does Not Reduce Macular Edema or Treatment Burden in Patients with Retinal Vein Occlusion: The RELATE Trial. Ophthalmology 2015; 122: 142637.
Song S, Yu X, Dai H. The efficacy of combination of Intravitreal Ranibizumab with triamcinolone or laser photocoagulation for macular edema secondary to branch retinal vein occlusion, Chin J Ocul Fundus Dis. 2015; 31:18–21.
Tan MH, Mcallister IL, Gillies ME, Verma N, Banerjee G, Smithies LA, Wong WL, Wong TY. Randomized controlled trial of intravitreal ranibizumab versus standard grid laser for macular edema following branch retinal vein occlusion. American Journal of Ophthalmology. 2014; 157(1):237-47.
Goel S, Kumar A, Ravani RD, Chandra P, Chandra M, Kumar V, Comparison of ranibizumab alone versus ranibizumab with targeted retinal laser for branch retinal vein occlusion with macular edema, Indian J Ophthalmol 2019;67:1105 8.
Terashima H, Hasebe H, Okamoto F, et al, Combination therapy of intravitreal ranibizumab and subthreshold micropulse photocoagulation for macular edema secondary to branch retinal vein occlusion: 6-month result April 23, 2018.