Study the Correlation of Diabetic Complications and Macrophage Erythroblast Attacher (MAEA) rs6815464 Gene Polymorphism

Matar, Hazem Samy; Abdelazeim, Esraa Adel; Sheir, Rania El-Sayed; Nasser, Mona Zaky Sherif; Ahmed, Mahmoud Hassan

doi:10.21608/ejmr.2023.221674.1416

Study the Correlation of Diabetic Complications and Macrophage Erythroblast Attacher (MAEA) rs6815464 Gene Polymorphism

Document Type : Original Article

Authors

¹ Internal Medicine department, Faculty of Medicine, Beni-Suef University, Egypt

² clinical pathology department, Faculty of Medicine, Beni-Suef University, Egypt

10.21608/ejmr.2023.221674.1416

Abstract

This study was designed to evaluate MAEA gene rs6815464 polymorphism as a risk factor of type 2 diabetes mellitus (T2DM) associated microangiopathic complications in the Egyptian population. Our patients were divided into two groups; diabetic patients with complications (30) recruited from Diabetes, endocrine and internal medicine clinic, Beni-Suef university hospital, compared with age and sex matched normal volunteers acting as a control group (61). Our study showed that diabetic retinopathy was the most common microangiopathic complication of T2DM (97%) followed by (90%) of the patients had diabetic nephropathy, while (70%) of the patients had diabetic neuropathy. Nonalcoholic fatty liver disease (NAFLD) was significantly higher in diabetic patients than in controls (p < 0.0001*). No significant correlation of MAEA rs6815464 polymorphism with the occurrence of diabetic microangiopathic complications was observed.

Keywords

Main Subjects

Internal medicine ·

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