The Effect of Topical 5-Fluorouracil Application on Preventing Nasal Adhesions after Endoscopic Partial Inferior Turbinectomy Combined with Submucous Resection of the Nasal Septum

Document Type : Original Article

Authors

1 Professor of Otorhinolaryngology Faculty of medicine Beni-Suef University

2 Professor of Otorhinolaryngology Faculty of Medicine- Beni-Suef University

3 M.B., B. CH Otorhinolaryngology department, Insurance hospital, Egypt

4 Lecturer of Otorhinolaryngology Faculty of medicine - Beni-Suef University

Abstract

Aim and background: In this research, we aimed to compare the nasal adhesion prevention after combined endoscopic partial inferior turbinectomy and submucous resection of the nasal septum between 5-fluorouracil and silastic. Patients and methods: 50 individuals with persistent nasal obstruction brought on by hypertrophy of the inferior turbinates and a deviated nasal septum who had not responded to medical therapy were the subject of this investigation. With a mean age of 25, they ranged in age from 16 to 56. 26 patients were men and 24 were women. 25 of these patients were placed in group A (the fluorouracil group), and 25 were placed in group B. (silastic group). Results: Regarding preoperative data, there was no statistically significant difference between the two groups. Conclusion: Our data and statistical analysis revealed that 5-FU application during endoscopic partial inferior turbinectomy combined with submucous resection of the nasal septum is an easy, effective, and safe method in reducing and preventing formation of adhesions as silastic sheet with a significantly lower postoperative pain, headache, and nasal obstruction than silastic in the first week postoperative.

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References

  1. Anand, V., Tabaee, A., Kacker, A., Newman, J. and Huang, C. (2004): The role of mitomycin C in preventing synechia and stenosis after endoscopic sinus surgery. American journal of rhinology; 18(5): 311-314.‏‏
  2. Baradaranfar, M., Khadem, J., Zahir, S., Kouhi, A., Dadgarnia, M. and Baradarnfar, A. (2011): Prevention of adhesion after endoscopic sinus surgery: role of mitomycin C. Acta Medica Iranica; 49(3): 131-135.‏
  3. Catalano, P. and Roffman, E. (2003): Evaluation of middle meatal stenting after minimally invasive sinus techniques (MIST). Otolaryngology-Head and Neck Surgery; 128(6): 875–881.
  4. Gupta, M. and Motwani, G. (2006): Role of mitomycin C in reducing adhesion formation following endoscopic sinus surgery. The Journal of Laryngology & Otology; 120(11): 921-923.
  5. Longley, D., Harkin, D. and Johnston, P. (2003): 5-fluorouracil: mechanisms of action and clinical strategies. Nature reviews cancer; 3(5): 330.
  6. Singh, R., Goldberg, I. and Mohsin, M. (2001): The efficacy and safety of intraoperative and/or postoperative 5-fluorouracil in trabeculectomy and phacotrabeculectomy. Clinical & Experimental Ophthalmology; 29(5): 296–302.
  7. Poulin, Y., Lynde, C. and Barber, K. (2015): Non-melanoma skin cancer in Canada chapter 3: management of actinic keratosis. Journal of cutaneous medicine and surgery; 19(3): 227–238.
  8. Weber, R. and Hosemann, W. (2015): Comprehensive review on endonasal endoscopic sinus surgery. GMS Current Topics in Otorhinolaryngology, Head and Neck Surgery; 14.
  9. Chul, C., Sung, M., Jin, H., Jung, S. and Heung, M. (2014): A Randomized, Multi-Center, Single Blind, Active-Controlled, Matched Pairs Clinical Study to Evaluate Prevention of Adhesion Formation After Endoscopic Sinus Surgery. Clinical and Experimental Otorhinolaryngology; 7(1): 30-35.
  10. Tabaee, A., Brown, S. and Anand, V. (2007): Mitomycin C and endoscopic sinus surgery. Current Opinion in Otolaryngology and Head and Neck Surgery; 15(1): 40–43.
  11. Nuseir, A., Alsalem, M., Alzahr, M., Ababneh, M., Alomari, A. and Alzoubi, F. (2017): The effect of topical 5-flurouracil application post endoscopic inferior turbinoplasty. American journal of otolaryngology; 38(2): 135-138.
  12. ‏ Amjad, N., Ahmad, A., Firas, A. and Bassam, E. (2017): Intranasal splints (INS) using empty intravenous fluid bottles, Effectiveness, and morbidity. Jordan Medical Journal; 51(4).
  13. Ulualp, S. (2008): Complications of endoscopic sinus surgery: appropriate management of complications. Current opinion in otolaryngology & head and neck surgery; 16(3): 252-259.

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