Relation Between Kidney Injury Molecule 1 (KIM 1) And Diabetic Nephropathy

Document Type : Original Article

Authors

1 Department of Internal Medicine, Faculty of Medicine, Beni-Suef University.

2 Department of Clinical and Chemical Pathology, Faculty of Medicine, Beni-Suef University.

Abstract

Background: Diabetic nephropathy is a chronic disorder that takes years to develop and is characterized by a progressive rise in urinary albumin secretion. It is one of the primary consequences of diabetes mellitus. Aim and objectives: To investigate the relation between kidney injury molecule1 (KIM1) and diabetic nephropathy. Patients and methods: This was a case control research performed on 100 subjects at internal medicine department of beni-suef university hospital. Thecases were separated into 4 groups. Results: KIM -1 showed  statistically significant varianceamongst the four studied groups with P value ( <0.001) ;In Control group KIM-1 varied from 1.70 to 27.50 with mean ± SD = 12.21 ± 7.249 , In normo-albuminuric group  KIM-1 ranged from 21 to 36.90 with mean  ± SD = 27.11 ± 4.48 ,  in micro-albuminuric group KIM-1 ranged from 10.1 to 53 with mean ± SD= 42.8 ± 9.33,inmacro- albuminuric group KIM-1 ranged from.69.to 81.5 with mean ± SD = 75.5 ± 4.03. Conclusion:Our study revealed increase of serum KIM 1 levels with development of Diabetic Nephropathy, reflecting the important role of Kim-1-as a biomarker for early diagnosis-and progression of DN. Serum Kim-1 is recommended to be utilized as a warning system for the development of diabetic nephropathy in people with diabetes as a screening test.

Keywords

Main Subjects

References

  1. EL-ASHMAWY, Nahla E., et al. Kidney injury molecule-1 (Kim-1): an early biomarker for nephropathy in type II diabetic patients. International Journal of Diabetes in Developing Countries, 2015, 35: 431-438.‏
  2. UWAEZUOKE, Samuel N. The role of novel biomarkers in predicting diabetic nephropathy: a review. International journal of nephrology and renovascular disease, 2017, 221-231.‏
  3. CAMPION, Carole G.; SANCHEZ-FERRAS, Oraly; BATCHU, Sri N. Potential role of serum and urinary biomarkers in diagnosis and prognosis of diabetic nephropathy. Canadian journal of kidney health and disease, 2017, 4: 2054358117705371.‏
  4. Gohda, T., Kamei, N., Koshida, T., Kubota, M., Tanaka, K., Yamashita, Y., Adachi, E., Ichikawa, S., Murakoshi, M., Ueda, S. and Suzuki, Y., (2020). Circulating kidney injury molecule‐1 as a biomarker of renal parameters in diabetic kidney disease. Journal of diabetes investigation, 11(2), pp.435-440.
  5. YANG, Li, et al. KIM-1–mediated phagocytosis reduces acute injury to the kidney. The Journal of clinical investigation, 2015, 125.4: 1620-1636.‏
  6. SONG, Lianlian, et al. Kidney injury molecule-1 expression is closely associated with renal allograft damage. Bosnian journal of basic medical sciences, 2013, 13.3: 170.
  7. SABBISETTI, Venkata S., et al. Blood kidney injury molecule-1 is a biomarker of acute and chronic kidney injury and predicts progression to ESRD in type I diabetes. Journal of the American Society of Nephrology: JASN, 2014, 25.10: 2177.
  8. BALU, Divya, et al. Does serum kidney injury molecule-1 predict early diabetic nephropathy: A comparative study with microalbuminuria. Annals of African Medicine, 2022, 21.2: 136.
  9. ABID KHAN, Fatima, et al. Evaluation of kidney injury molecule-1 as a disease progression biomarker in diabetic nephropathy: KIM-1 and Diabetic Nephropathy. Pakistan Journal of Medical Sciences, 2019, 35.4: 992-996.
  10. QUANG, Thuan Huynh, et al. Evaluation of urinary neutrophil gelatinase associated lipocalin and kidney injury molecule-1 as diagnostic markers for early nephropathy in patients with type 2 diabetes mellitus. Diabetes, Metabolic Syndrome and Obesity, 2020, 2199-2207.
  11. AHMED, Glonar Otiefy; MORSY, Amal Abdel Aleem; ABO EL ENEEN, Samah Roshdy Abo El Eneen. Role of kidney injury molecule-1 and β2-microglobulin in early diagnosis of diabetic nephropathy. The Egyptian Journal of Hospital Medicine, 2019, 75.2: 2276-2284.
  12. ASLAN, Ozgur; DEMIR, Metin; KOSEOGLU, Mehmet. Kidney injury molecule levels in type 2 diabetes mellitus. Journal of Clinical Laboratory Analysis, 2016, 30.6: 1031-1036.

 

Files

Share

How to cite

Statistics