Possible Impacts of Vitamin-D Supplements on Uterine Fibroid

Document Type : Original Article

Authors

1 Obstetrics and Gynecology Department, Faculty of Medicine, Beni-Suef University

2 Department of Medical Physiology, faculty of Medicine, Beni-Suef University

Abstract

Background: Uterine fibroids, which are non-cancerous tumors found in the pelvic region, are prevalent among women of reproductive age. The incidence of uterine fibroids varies between 5.4% and 77%. These tumors develop within the muscular walls of the uterus in women who have not yet reached menopause. Symptomless or causing abnormal bleeding, pelvic pressure symptoms, infertility, and growth or regress throughout life, leiomyomas are more common in people of African descent, those who have never given birth, those who are overweight, and those with a positive family history of fibroids. Millions of women suffer with leiomyoma, and it is one of the most common reasons for hysterectomy. Aim of the Work: to determine whether or not vitamin D supplementation reduces the size of uterine fibroids in patients who are deficient in the nutrient. Patients and Methods: This RCT was a single-blind randomized study at tertiary care hospital at Beni-Suef university hospital from January 2022 till June 2022 and performed on a total of 100 women in childbearing period diagnosed with uterine fibroid who had vitamin- D deficiency. Results: As regards the fibroid size after Vitamin D supplementation for 6 months, according to the findings of this study, there is no statistically significant distinction in fibroid size amongst Vitamin D group and control group over the first three months whereas, fibroid size was substantially less in the Vitamin D group. At the fourth, fifth month and sixth months. Consequently, the size of the tumor decreased significantly over the six months in the group of Vitamin D supplementation with no significant improvement in the size of the fibroid over the 6 months in the control group. Conclusion: According to the results of the current research, vitamin D supplementation is an effective, low-risk method of preventing leiomyoma growth and stabilizing fibroids, therefore avoiding the onset of more serious and symptomatic disorders. Vitamin D supplementation seems to prevent fibroid growth.

Keywords

Main Subjects

References

  1.  

    1. Parker, W. H. (2007). Etiology, symptomatology, and diagnosis of uterine myomas. Fertility and sterility, 87(4), 725-736.
    2. Wise, L. A., & Laughlin-Tommaso, S. K. (2016). Epidemiology of uterine fibroids–from menarche to menopause. Clinical obstetrics and gynecology, 59(2), 285-306.
    3. Ross, A. C. (2011). The 2011 report on dietary reference intakes for calcium and vitamin D. Public health nutrition, 14(5), 938-939.
    4. Gorham, E. D., Garland, C. F., Garland, F. C., Grant, W. B., Mohr, S. B., Lipkin, M., & Holick, M. F. (2007). Optimal vitamin D status for colorectal cancer prevention: a quantitative meta analysis. American journal of preventive medicine, 32(3), 210-216.
    5. Burns, E. M., Elmets, C. A., & Yusuf, N. (2015). Vitamin D and skin cancer. Photochemistry and photobiology, 91(1), 201-209.
    6. Luk, J., Torrealday, S., Neal Perry, G., & Pal, L. (2012). Relevance of vitamin D in reproduction. Human reproduction, 27(10), 3015-3027.
    7. Halder, S. K., Osteen, K. G., & Al-Hendy, A. (2013). Vitamin D3 inhibits expression and activities of matrix metalloproteinase-2 and-9 in human uterine fibroid cells. Human reproduction, 28(9), 2407-2416.
    8. Arjeh, S., Darsareh, F., Asl, Z. A., & Kutenaei, M. A. (2020). Effect of oral consumption of vitamin D on uterine fibroids: A randomized clinical trial. Complementary Therapies in Clinical Practice, 39, 101159.
    9. Sheng, B., Song, Y., Liu, Y., Jiang, C., & Zhu, X. (2020). Association between vitamin D and uterine fibroids: A study protocol of an open-label, randomised controlled trial. BMJ open, 10(11), e038709.
    10. Tanha, F. D., Feizabad, E., Farahani, M. V., Amuzegar, H., Moradi, B., & Sadeh, S. S. (2021). The effect of vitamin D deficiency on overgrowth of uterine fibroids: a blinded randomized clinical trial. International Journal of Fertility & Sterility, 15(2), 95-100.
    11. Vahdat, M., Allahqoli, L., Mirzaei, H., Giovannucci, E., Salehiniya, H., Mansouri, G., & Alkatout, I. (2022). The effect of vitamin D on recurrence of uterine fibroids: A randomized, double-blind, placebo-controlled pilot study. Complementary Therapies in Clinical Practice, 46, 101536.
    12. Trefoux Bourdet, A., Luton, D., & Koskas, M. (2015). Clinical utility of ulipristal acetate for the treatment of uterine fibroids: current evidence. International journal of women's health, 321-330.
    13. Guo, X. C., & Segars, J. H. (2012). The impact and management of fibroids for fertility: an evidence-based approach. Obstetrics and Gynecology Clinics, 39(4), 521-533.
    14. Bikle, D. D. (2009). Vitamin D and immune function: understanding common pathways. Current osteoporosis reports, 7(2), 58-63.
    15. Al-Hendy, A., & Badr, M. (2014). Can vitamin D reduce the risk of uterine fibroids?. Women’s Health, 10(4), 353-358.
    16. Baird, D. D., Hill, M. C., Schectman, J. M., & Hollis, B. W. (2013). Vitamin D and risk of uterine fibroids. Epidemiology (Cambridge, Mass.), 24(3), 447-453.
    17. Ciavattini, A., Carpini, G. D., Serri, M., Vignini, A., Sabbatinelli, J., Tozzi, A., & Clemente, N. (2016). Hypovitaminosis D and “small burden” uterine fibroids: Opportunity for a vitamin D supplementation. Medicine, 95(52), e5698.
    18. Halder, S. K., Sharan, C., & Al-Hendy, A. (2012). 1,25-dihydroxyvitamin D3 treatment shrinks uterine leiomyoma tumors in the Eker rat model. Biology of reproduction, 86(4), 116-121.
    19. Paffoni, A., Somigliana, E., Vigano', P., Benaglia, L., Cardellicchio, L., Pagliardini, L., & Fedele, L. (2013). Vitamin D status in women with uterine leiomyomas. The Journal of Clinical Endocrinology & Metabolism, 98(8), E1374-E1378.
    20. Rosen, L. D., Fenske, S. K., Isola, H. M., & Ascher-Walsh, C. J. (2018). Vitamin D deficiency in women with uterine fibroids versus Vitamin D deficiency in the general population. Clin Obstet Gynecol Reprod Med, 4(6), 1-3.
    21. Oskovi Kaplan, Z. A., Taşçi, Y., Topçu, H. O., & Erkaya, S. (2018). 25-Hydroxy vitamin D levels in premenopausal Turkish women with uterine leiomyoma. Gynecological Endocrinology, 34(3), 261-264.
    22. Mitro, S. D., & Zota, A. R. (2015). Vitamin D and uterine leiomyoma among a sample of US women: Findings from NHANES, 2001–2006. Reproductive Toxicology, 57, 81-86.
    23. Brakta, S., Diamond, J. S., Al-Hendy, A., Diamond, M. P., & Halder, S. K. (2015). Role of vitamin D in uterine fibroid biology. Fertility and sterility, 104(3), 698-706.

Files

Share

How to cite

Statistics