Sensitivity of functional connectivity analysis in diagnosis of idiopathic childhood focal epilepsies.

Document Type : Original Article

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1 Clinical Neurophysiology department, Faculty of Medicine, Beni-Suef University, Egypt.

2 Department of Pediatrics, Faculty of Medicine, Beni-Suef University, Beni-Suef,, Egypt.

Abstract

Background, Idiopathic childhood epilepsy causing an alteration in the brain functional connectivity including increased neuronal excitability, establishment of critical interconnections and perhaps causing complicated structural changes. The aim of our work is to study the changes in EEG functional connectivity (coherence and phase lag) among children with different types of idiopathic epilepsy in comparison to normal controls. Subjects and methods: This case-control research conducted on fifteen subjects with newly diagnosed idiopathic childhood epilepsy and fifteen age & sex-matched healthy controls. Both groups were subjected to clinical history taking, routine EEG by using the international 10-20 system and the data analyzed using the quantitative electroencephalography (QEEG) to detect the impact of interictal epileptiform activity on the brain functional connectivity. Results: There is an interictal reduction in the brain functional connectivity, in specific frequency bands, in patients with idiopathic focal epilepsy. Conclusion: In idiopathic focal epilepsy, there is an alteration in the brain functional connectivity only in specific frequency bands. 
 

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