Prevalence of Helicobacter pylori infection in pregnant women with hyperemesis gravidarum

Katta, Maha Ali; Ali, Reem Ramadan; Sayed, Sayed Mohamed

doi:10.21608/ejmr.2024.280233.1596

Prevalence of Helicobacter pylori infection in pregnant women with hyperemesis gravidarum

Document Type : Original Article

Authors

Obstetrics and Gynecology Department, Faculty of Medicine, Beni-Suef University, Egypt.

10.21608/ejmr.2024.280233.1596

Abstract

Background: Hyperemesis Gravidarum (HEG) is the most frequent reason for hospitalization in early pregnancy. The exact etiology is unknown and likely multifactorial. The Helicobacter pylori (H.pylori) infection is linked to peptic ulcers and possibly other gastric disorders. Aim: to determine the prevalence of Helicobacter Pylori infection in pregnant women with hyperemesis gravidarum. Methods: This is a cross-sectional study of 143 women with HEG. They were subjected to clinical assessment and the Pregnancy Unique Quantification of Emesis (PUQE) questionnaire. Routine ultrasonographic and laboratory evaluations were done, and stool testing for H. pyri infection was performed using the IgM ELISA technique. Results: 20 patients (14%) had PUQE scores ≥13, consistent with severe disease. H.pylori was positive in 69 patients (48%), including 75% of those with severe disease (p=0.031). Those with positive H.pylori results had younger ages and were more frequently primigravidae. Conclusion: Helicobacter pylori infection is common in pregnant women with HEG, particularly those with severe disease.

Keywords

Main Subjects

Surgery ·

References

McParlin C, O’Donnell A, Robson SC, Beyer F, Moloney E, Bryant A, Bradley J, Muirhead CR, Nelson-Piercy C, Newbury-Birch D, Norman J. Treatments for hyperemesis gravidarum and nausea and vomiting in pregnancy: a systematic review. Jama. 2016 Oct 4;316(13):1392-401.
Nurmi M, Rautava P, Gissler M, Vahlberg T, Polo-Kantola P. Recurrence patterns of hyperemesis gravidarum. American Journal of Obstetrics and Gynecology. 2018 Nov 1;219(5):469-e1.
London V, Grube S, Sherer DM, Abulafia O. Hyperemesis gravidarum: a review of recent literature. Pharmacology. 2017 Jun 23;100(3-4):161-71.
Donahue S. HYPEREMESIS GRAVIDARUM-INDUCED WERNICKE'S ENCEPHALOPATHY. Chest. 2018 Oct 1;154(4):233A.
White S, Byrne J, McIntire DD, Nelson DB. Hyperemesis Gravidarum: Can Factors Predict Risk of Readmission?[21L]. Obstetrics & Gynecology. 2018 May 1;131:134S-5S.
Koren G, Cohen R. Measuring the severity of nausea and vomiting of pregnancy; a 20-year perspective on the use of the pregnancy-unique quantification of emesis (PUQE). Journal of Obstetrics and Gynaecology. 2021 Apr 3;41(3):335-9.
Stefano K, Marco M, Federica G, Laura B, Barbara B, Gioacchino L, Gian LD. Helicobacter pylori, transmission routes and recurrence of infection: state of the art. Acta Bio Medica: Atenei Parmensis. 2018;89(Suppl 8):72.
Li J, Fan M, Ma F, Zhang S, Li Q. The effects of Helicobacter pylori infection on pregnancy-related diseases and fetal development in diabetes in pregnancy. Annals of Translational Medicine. 2021 Apr;9(8).
Graham DY, Miftahussurur M. Helicobacter pylori urease for diagnosis of Helicobacter pylori infection: A mini review. Journal of advanced research. 2018 Sep 1;13:51-7.
Bessède E, Arantes V, Mégraud F, Coelho LG. Diagnosis of Helicobacter pylori infection. Helicobacter. 2017 Sep;22:e12404.
Boelig RC. The dilemma of hyperemesis gravidarum: more answers, and more questions. The American Journal of Clinical Nutrition. 2017 Mar 1;106(3):711-2.
Kabir S, Khanam RA, Basher MS, Azam MS, Hossain MA, Mirza TT, Banu KA, Karmoker RK. Helicobacter Pylori Stool Antigen Assay in Hyperemesis Gravidarum. Mymensingh Medical Journal: MMJ. 2017 Apr 1;26(2):250-5.
Owe KM, Støer N, Wold BH, Magnus MC, Nystad W, Vikanes ÅV. Leisure-time physical activity before pregnancy and risk of hyperemesis gravidarum: a population-based cohort study. Preventive Medicine. 2019 Aug 1;125:49-54.
Broussard CN, Richter JE. Nausea and vomiting of pregnancy. Gastroenterology Clinics of North America. 1998 Mar 1;27(1):123-51.
Salimi-Khayati A, Sharami H, Mansour-Ghanaei F, Sadri S, Fallah MS. Helicobacter pylori seropositivity and the incidence of hyperemesis gravidarum. Medical Science Monitor: International Medical Journal of Experimental and Clinical Research. 2003 Jan 1;9(1):CR12-5.
Khoder G, Muhammad JS, Mahmoud I, Soliman SS, Burucoa C. Prevalence of Helicobacter pylori and its associated factors among healthy asymptomatic residents in the United Arab Emirates. Pathogens. 2019 Apr 1;8(2):44.
Kouitcheu Mabeku LB, Noundjeu Ngamga ML, Leundji H. Potential risk factors and prevalence of Helicobacter pylori infection among adult patients with dyspepsia symptoms in Cameroon. BMC infectious diseases. 2018 Dec;18:1-1.
Zhou Q. A novel risk classification system for preconception health and sero-epidemiological map of Toxoplasma, Rubella and Cytomegalovirus infections among couples planning a pregnancy in rural China: A nationwide study.
Park JY, Forman D, Waskito LA, Yamaoka Y, Crabtree JE. Epidemiology of Helicobacter pylori and CagA-positive infections and global variations in gastric cancer. Toxins. 2018 Apr 19;10(4):163.
Karakus C, Ulupinar Z, Akbas F, Yazici D. Detection of Anti-CagA Antibodies in Sera of Helicobacter pylori-Infected Patients Using an Immunochromatographic Test Strip. Journal of Chromatographic Science. 2020 Mar;58(3):217-22.
Okushin K, Tsutsumi T, Ikeuchi K, Kado A, Enooku K, Fujinaga H, Moriya K, Yotsuyanagi H, Koike K. Helicobacter pylori infection and liver diseases: Epidemiology and insights into pathogenesis. World Journal of Gastroenterology. 2018 Aug 8;24(32):3617.
Ahmed MA, Ali AA, Mohammad ZA, Abdallah EA. Prevalence of Helicobacter Pylori Infection in Pregnant Women with Hyperemesis Gravidarum. SVU-International Journal of Medical Sciences. 2023 Jul 1;6(2):522-30.
Hooi JK, Lai WY, Ng WK, Suen MM, Underwood FE, Tanyingoh D, Malfertheiner P, Graham DY, Wong VW, Wu JC, Chan FK. Global prevalence of Helicobacter pylori infection: systematic review and meta-analysis. Gastroenterology. 2017 Aug 1;153(2):420-9.