Background: Vitiligo is an acquired epidermal pigment loss of the skin. Oxidative stress is one of the major theories in the pathophysiology of vitiligo. FOXO1 is the forkhead members of the class O (FOXO1) transcription factors, and plays an important role in cell cycle regulation, apoptosis, oxidative stress, and DNA repair. Aim of the Work: to detect the level of FOXO1 in patients with vitiligo. Subjects and Methods: Fifty patients with Vitiligo were included in the study, and fifty healthy controls matched in age and gender to Vitiligo cases. All participants were subjected to full clinical and laboratory investigations. Blood samples had been taken from all studied participants (Vitiligo cases and healthy controls) to study serum level of FOXO1 and its relationship with the pathogenesis of vitiligo. Results: Serum level of FOXO1 was significantly higher in Vitiligo patients as compared with healthy controls, serum level of FOXO1 was slightly higher in female’s Vitiligo serum as compared with males; but with no statistically significant difference, serum level of FOXO1 was slightly higher in Vitiligo serum among patients with positive as compared with negative family history but with no statistically significant difference. There was non-statistically significant linear correlation between serum level of FOXO1 and patients’ age, disease duration and last new lesion, however, there was a statistically significant positive linear correlation between serum level of FOXO1 and Vitiligo Area Scoring Index (VASI) in studied Vitiligo patients. Conclusion: We can conclude that, FOXO1 might be associated with susceptibility to vitiligo, especially active vitiligo, and that increased FOXO1 levels in vitiligo patients might be associated with oxidative stress.
Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993). A C. elegans mutant that lives twice as long as wild type. Nature, 366(6454), 461-464.
Ezzedine, K., Lim, H. W., Suzuki, T., Katayama, I., Hamzavi, I., Lan, C. C. E., & Vitiligo Global Issue Consensus Conference panelists. (2012). Revised classification/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference. Pigment cell & melanoma research, 25(3), E1-E13.
Shah, R., Hunt, J., Webb, T. L., & Thompson, A. R. (2014). Starting to develop self‐help for social anxiety associated with vitiligo: using clinical significance to measure the potential effectiveness of enhanced psychological self‐help. British Journal of Dermatology, 171(2), 332-337.
Hwangbo, D. S., Gersham, B., Tu, M. P., Palmer, M., & Tatar, M. (2004). Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature, 429(6991), 562-566.
Liu, P., Pazin, D. E., Merson, R. R., Albrecht, K. H., & Vaziri, C. (2009). The developmentally-regulated Smoc2 gene is repressed by Aryl-hydrocarbon receptor (Ahr) signaling. Gene, 433(1-2), 72-80.
Dammak, I., Boudaya, S., Ben Abdallah, F., Turki, H., Attia, H., & Hentati, B. (2009). Antioxidant enzymes and lipid peroxidation at the tissue level in patients with stable and active vitiligo. International journal of dermatology, 48(5), 476-480.
Wang, Y., Zhou, Y., & Graves, D. T. (2014). FOXO transcription factors: their clinical significance and regulation. BioMed research international, 2014.
Hamzavi, I., Jain, H., McLean, D., Shapiro, J., Zeng, H. and Lui, H. (2004). Parametric modeling of narrowband UV-B phototherapy for vitiligo using a novel quantitative tool: the Vitiligo Area Scoring Index. Archives of Dermatology, 140(6), pp.677-683.
Fredriksson, T. and Pettersson, U. (1978). Severe psoriasis–oral therapy with a new retinoid. Dermatology, 157(4), pp.238-244.
Bakry, O., Elhefnawy, S., Seliet, E., & Omar, M. A. (2020). Determination of oxidative stress in vitiligo by measuring superoxide dismutase levels in vitiliginous skin. Menoufia Medical Journal, 33(1), 262.
Boniface, K., Seneschal, J., Picardo, M., & Taïeb, A. (2018). Vitiligo: focus on clinical aspects, immunopathogenesis, and therapy. Clinical reviews in allergy & immunology, 54(1), 52-67.
Hayran, Y., Özge Ergen, G., & Özmen, F. (2021). The relationship between non‐segmental Vitiligo, HLA genotype and oxidative stress. International Journal of Clinical Practice, 75(3), e14024.
Egea, G., Jiménez-Altayó, F., & Campuzano, V. (2020). Reactive oxygen species and oxidative stress in the pathogenesis and progression of genetic diseases of the connective tissue. Antioxidants, 9(10), 1013.
Chen, J., Liu, Y., Zhao, Z., & Qiu, J. (2021). Oxidative stress in the skin: Impact and related protection. International Journal of Cosmetic Science, 43(5), 495-509.
Tia, N., Singh, A. K., Pandey, P., Azad, C. S., Chaudhary, P., & Gambhir, I. S. (2018). Role of Forkhead Box O (FOXO) transcription factor in aging and diseases. Gene, 648, 97-105.
Zhang, Y., Xiong, Y., Zhou, J., Xin, N., Zhu, Z., & Wu, Y. (2018). FoxO1 expression in osteoblasts modulates bone formation through resistance to oxidative stress in mice. Biochemical and biophysical research communications, 503(3), 1401-1408.
Murtaza, G., Khan, A. K., Rashid, R., Muneer, S., Hasan, S. M. F., & Chen, J. (2017). FOXO transcriptional factors and long-term living. Oxidative medicine and cellular longevity, 2017.
Wang, S., Xia, P., Huang, G., Zhu, P., Liu, J., Ye, B., & Fan, Z. (2016). FoxO1-mediated autophagy is required for NK cell development and innate immunity. Nature communications, 7(1), 1-15.
Sendrasoa, F. A., Ranaivo, I. M., Sata, M., Andrianarison, M., Raharolahy, O., Rakotoarisaona, M., & Rapelanoro Rabenja, F. (2019). Treatment responses in patients with Vitiligo to very potent topical corticosteroids combined with vitaminotherapy in Madagascar. International journal of dermatology, 58(8), 908-911.
Dong, Y., Yang, Q., Guo, B., Zhu, J., & Sun, X. (2021). The effects of tacrolimus plus phototherapy in the treatment of vitiligo: a meta-analysis. Archives of Dermatological Research, 313(6), 461-471.
Gupta, V. P. (2020). Clinico demographic evaluation of vitiligo and associated autommune disorders: A prospective study in up region.
Nejad, S. B., Qadim, H. H., Nazeman, L., Fadaii, R., & Goldust, M. (2013). Frequency of autoimmune diseases in those suffering from vitiligo in comparison with normal population. Pakistan journal of biological sciences: PJBS, 16(12), 570-574.
Poojary, S. A. (2011). Vitiligo and associated autoimmune disorders: A retrospective hospital-based study in Mumbai, India. Allergologia et immunopathologia, 39(6), 356-361.
Xing, Y. Q., Li, A., Yang, Y., Li, X. X., Zhang, L. N., & Guo, H. C. (2018). The regulation of FOXO1 and its role in disease progression. Life sciences, 193, 124-131.
Agatemor, C., Middleton, S. A. D., & Toledo, D. (2021). How pervasive are post-translational and-transcriptional modifications?. Trends in cell biology.
Tiwari, H. S., Misra, U. K., Kalita, J., Mishra, A., & Shukla, S. (2016). Oxidative stress and glutamate excitotoxicity contribute to apoptosis in cerebral venous sinus thrombosis. Neurochemistry international, 100, 91-96.
Arakaki, K., Chinen, K., Kamiya, M., Tanabe, Y., Tawata, N., Ikehara, F., ... & Kinjo, T. (2014). Evidence for an association between increased oxidative stress and derangement of FOXO1 signaling in tumorigenesis of a cellular angiofibroma with monoallelic 13q14: a case report. International journal of clinical and experimental pathology, 7(12), 8972.
Said, E. R., Nagui, N. A. E. R., Rashed, L. A., & Mostafa, W. Z. (2021). Oxidative stress and the cholinergic system in non‐segmental vitiligo: Effect of narrow band ultraviolet b. Photodermatology, Photoimmunology & Photomedicine.
Samaka, R.M., Basha, M.A. and Menesy, D. (2019). Role of Janus kinase 1 and signal transducer and activator of transcription 3 in vitiligo. Clinical, Cosmetic and Investigational Dermatology, 12, p.469.
Storz, P. (2011). Forkhead homeobox type O transcription factors in the responses to oxidative stress. Antioxidants & redox signaling, 14(4), pp.593-605.
Gohary, Y., Rashed, L., Osman, R., & Kamel, H. (2024). Detection of Serum Level of Forkhead Box O1 (FOXO1) in Patients of Vitiligo and It’s Correlation with Disease Severity. Egyptian Journal of Medical Research, 5(4), -. doi: 10.21608/ejmr.2023.197154.1356
MLA
Yasser Mostafa Gohary; Laila Ahmed Rashed; Rehab Emad Osman; Hanan Abd Elrazek Kamel. "Detection of Serum Level of Forkhead Box O1 (FOXO1) in Patients of Vitiligo and It’s Correlation with Disease Severity", Egyptian Journal of Medical Research, 5, 4, 2024, -. doi: 10.21608/ejmr.2023.197154.1356
HARVARD
Gohary, Y., Rashed, L., Osman, R., Kamel, H. (2024). 'Detection of Serum Level of Forkhead Box O1 (FOXO1) in Patients of Vitiligo and It’s Correlation with Disease Severity', Egyptian Journal of Medical Research, 5(4), pp. -. doi: 10.21608/ejmr.2023.197154.1356
VANCOUVER
Gohary, Y., Rashed, L., Osman, R., Kamel, H. Detection of Serum Level of Forkhead Box O1 (FOXO1) in Patients of Vitiligo and It’s Correlation with Disease Severity. Egyptian Journal of Medical Research, 2024; 5(4): -. doi: 10.21608/ejmr.2023.197154.1356