Evaluation of chitinase -3-like protein 1 Level in Patients with lichen planus

Abd-Elatif, Mona El Sayed Ahmed; Ali, Esraa Mohamed Emam; Rashed, Laila Ahmed; Naguib, Reham William

doi:10.21608/ejmr.2022.133135.1220

Evaluation of chitinase -3-like protein 1 Level in Patients with lichen planus

Document Type : Original Article

Authors

¹ Dermatology department, Faculty of Medicine, Beni-Suef University

² Biochemistry department, Faculty of Medicine, Cairo University

10.21608/ejmr.2022.133135.1220

Abstract

Lichen planus (LP) is an idiopathic, chronic, inflammatory, autoimmune dermatological disorder characterized by keratinocytes apoptosis. The pathogenesis of LP appears multifactorial. chitinase-3-like protein1(CHI3L1) has been found to play a role in inflammation, proliferation and angiogenesis. The aim of the current study was to evaluate tissue CHI3L1 levels in skin biopsies of LP patients to investigate its role in LP pathogenesis. In 30 LP patients and 30 healthy controls, CHI3L1 level was estimated using Polymerase Chain Reaction (PCR) technique. The expression of CHI3L1 was significantly higher in tissue biopsies from LP lesions in comparison to normal control biopsies. Thus, CHI3L1 might participate in the pathogenesis of LP.

Keywords

Main Subjects

Internal medicine ·

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