Audiological Profile in Patients with Tinnitus accompanied with Vitamin B12 Deficiency

Document Type : Original Article

Authors

1 Audiovestibular medicine unit ,ENT department ,faculty of medicine

2 audiovestibular medicine unit ,ENT department,faculty of medicine ,Beni suef university

3 Radiology Department ,faculty of medicine Beni suef university

4 Clinical and chemical department , faculty of medicine ,Beni suef university

5 Otolaryngology department, audiovestibular medicine unit, faculty of medicine, Bani Suef University, Bani Suef, Egypt

6 Audiovestibular medicine unit ,ENT department,faculty of medicine Beni suef university

Abstract

Background: Vitamin B12 is a necessary in the methylation response, which results in the formation of myelin. A lack of vitamin B12 may result in demyelination of nerve cells in the cochlear nerve, resulting in hearing loss and tinnitus. Aim of this work: To analyze the effect of Vitamin B12 deficiency on auditory brain stem response and otoacoustic emission in patients suffering from tinnitus. Patients and Methods: This was a case-control study with 6 male (20.0%) and 24 female (80.0%) with tinnitus as cases (30 participants) and 7 male (23.3%) and 23 female (76.6%) as controls (30 participants). Pure tone audiometry, Auditory Brain Stem Response, Transient evoked otoacoustic emissions ,Detection of the serum levels of Vitamin B12 and Conventional MRI brain were performed . Results: There was a statistically significant delay at wave III latency in cases than the controls in the right side while in the left side, wave I and III latencies were statistically significant prolonged in cases than the controls..There was no statistically significant correlation between vitamin B12 level and the latency or amplitude of auditory brainstem responses. Conclusion:Our findings imply that auditory brain stem response results in patients with tinnitus linked with vitamin B12 deficiency can be impacted.

Keywords

Main Subjects

References

 
1-Green R, Allen LH and  Bjørke-Monsen AL(2017): Vitamin B 12 deficiency. Nat Rev Dis Primers,3:17040.
2- Partearroyo T, Vallecillo N, Pajares MA, Varela-Moreiras G and  Varela-Nieto I:Cochlear homocysteine metabolism at the crossroad of nutrition and sensorineural hearing loss. Front Mol Neurosci.;10:107.
3- Singh C, Kawatra R, Gupta J, Awasthi V and  Dungana H(2016): Therapeutic role of Vitamin B12 in patients of chronic tinnitus: A pilot study. Noise Health ,; 18: 93-97. doi: 10.4103/1463-1741.178485.

4- Kim JS(2018): Association between tinnitus and mental health among Korean adolescents: the Korea national health and nutrition examination survey, Cent. Eur. J. Publ. Health 26 ;65–70.

5- Quaranta A, Scaringi A and Bartoli R(2004): The effects of ‘supra-physiological’ vitamin B12 administration on temporary threshold shift. int J Audiol , 43: 162-165.
6- Demir N, Koç A, Abuhandan M, Çalık M and İşcan A(2015):Visual and brainstem auditory evoked potentials in infants withsevere vitamin B12 deficiency. Turkish journal of medical sciences, 45: 1274-1279.
7- Soliman SM, Fathalla A and Shehata M (1985): Development of Arabic staggered spondee words (SSW) test. In proceeding of 8th Ain Shams Med. Cog.
8-Soliman S (1976):Speech discrimination audiometry using Arabic phonetically balanced words. Ain Shams Med J. 27:27-30.
9- Karli R, Gül A and Uğur B (2013): Effect of vitamin B12 deficiency on otoacoustic emissions. Acta otorhinolaryngologica Italica: 33(4), 243–247.
10- Chhaya V, Patel D, Shethia F, Manchaiah V and Khambholja K (2021):Current Therapeutic Trends for Tinnitus Cure and Control: A Scoping Review. Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India, 1–9.
11- Norena AJ and Farley BJ (2013): Tinnitus-related neural activity: theories of generation, propagation, and centralization. Hearing research, 295, 161–171.
12- Houston DK, Johnson MA and  Nozza RJ(1999): Age related hearing loss, vitamin B-12, and folate in elderly women. Am J Clin nutr , 69: 564-571.
13- Petridou AI, Zagora ET, Petridis P, Korres GS, Gazouli M, Xenelis I, Kyrodimos E, Kontothanasi G and Kaliora AC (2019): The Effect of Antioxidant Supplementation in Patients with Tinnitus and Normal Hearing or Hearing Loss: A Randomized, Double-Blind, Placebo Controlled Trial. Nutrients, 11(12), 3037. 
14- Demir N, Koç A, Abuhandan M, Çalık M and İşcan A (2015): Visual and brainstem auditory evoked potentials in infants with severe vitamin B12 deficiency. Turkish journal of medical sciences, 45(6), 1274–1279.
15- Turan İ, Ünsal S and Kurtaran H (2020): Evaluation of Auditory Brainstem Response (ABR) in Vitamin B12 Deficiency. The international tinnitus journal, 24(2), 74–78.
16- Shemesh Z, Attias J, Ornan M, Shapira N and Shahar A (1993): Vitamin B12 deficiency in patients with chronic-tinnitus and noise-induced hearing loss. American journal of otolaryngology, 14(2), 94–99.
17-Bleich S, Degner D, Sperling W, Bönsch D, Thürauf N, Kornhuber J(2004). Homocysteine as a neurotoxin in chronic alcoholism. Prog. Neuropsychopharmacol. Biol. Psychiatry; 28: 453–64.
18- Thabet EM (2009): Evaluation of tinnitus patients with normal hearing sensitivity using TEOAEs and TEN test. Auris, nasus, larynx, 36(6), 633.
19- Kara E, Aydın K, Akbulut AA, Karakol SN, Durmaz S, Yener HM, Gözen ED and Kara H (2020): Assessment of Hidden Hearing Loss in Normal Hearing Individuals with and Without Tinnitus. The journal of international advanced otology, 16(1), 87–92.
20- Evim MS, Erdöl Ş, Özdemir Ö, Baytan B and Güneş AM (2011): Long-term outcome in children with nutritional vitamin B12 deficiency. Turkish journal of haematology : official journal of Turkish Society of Haematology, 28(4), 286–293.
21-Joo JW,Jeong YJ,Han MS ,Chang YS ,Rah YC and Choi J(2020) :Analysis of auditory brainstem response changes ,according to tinnitus duration,in patients with tinnitus with normal hearing. J Int Adv Otol; 16(2): 190-6 • DOI: 10.5152/iao.2020.7951.
22-Aedo C and Aguilar E (2020):  Cochlear synaptopathy: new findings in animal and human research. Reviews in the neurosciences, 31(6), 605–615.

Files

Share

How to cite

Statistics