Measurement of serum levels of interleukin 17 in acne vulgaris Patients and its relation to severity of the disease

Eltaweel, Abd El-Aziz Ibrahim; Ezz, Marmar Ahmed; Riad, Hoda Ramadan; Kamel, Hanan Abdelrazik

doi:10.21608/ejmr.2024.300692.1634

Measurement of serum levels of interleukin 17 in acne vulgaris Patients and its relation to severity of the disease

Document Type : Original Article

Authors

¹ Dermatology and Andrology Benha University

² Dermatology Department October 6 University

³ Biochemistry Department, Faculty of Medicine, Beni-Suef University, Egypt

⁴ Dermatology & Andrology Department, Faculty of Medicine, Beni-Suef University, Egypt

10.21608/ejmr.2024.300692.1634

Abstract

The purpose of this research was to examine the role of IL-17 in acne vulgaris (AV) patients especially in the development of scarring lesions, the severity of illness, and disease etiology. Fifty patients with AV of varied severity (Group A) were included in this case-control study from the Outpatient Clinic of the Dermatology Department at Beni Suef University Hospitals. Thirty healthy volunteers, matched for age and sex, made up the control group IL-17 serum levels were reviewed using ELIZA among study contributors. The age and sex distributions of the groups under study did not differ significantly. Mild acne accounted for 36% of the patients, moderate for 34%, and severe for 30%. Scarring was seen in 28% of the subjects in the present study. The levels of IL-17 were significantly higher in the case group when compared with the control group.
There are still gaps in our understanding of the pathophysiology of this common condition, and this study's results points to interrelationships between IL-17 and AV etiology

Keywords

Main Subjects

Diagnostic

References

1- Bhate K and Williams HC. Epidemiology of acne vulgaris. Br J Dermatol 2013; 168(3):474-485.

2- Williams HC, Dellavalle RP and Garner S. Acne vulgaris. Lancet 2012; 379: 361-372.

3- Zouboulis CC, Jourdan E, Picardo M. Acne is an inflammatory disease and alterations of sebum composition initiate acne lesions. J Eur Acad Dermatol Venereol 2014; 28: 527-532.

4- Chang, H.W.; Yan, D.; Singh, R.; et al. Alteration of the cutaneous microbiome in psoriasis and potential role in Th17 polarization. Microbiome 2018; 6: 154.

5- Ramli R, Malik AS, Hani AF, Jamil A. Acne analysis, grading and computational assessment methods: an overview. Skin research and technology. 2012 Feb;18(1):1-4.

6- Kelhälä H-L, Palatsi R, Fyhrquist N, et al. IL-17/Th17 pathway is activated in acne lesions. PLoS One 2014; 9(8): e105238.

7- Van den Berg WB and McInnes IB. Th17 cells and IL-17a: Focus on immunopathogenesis and immunotherapeutics. Semin Arthritis Rheum 2013; 43: 158-170.

8- Bilgic O, Dogdu M, Islamoglu GK et al. The relationship between the second to fourth digit ratio and acne vulgaris. J Eur Acad Dermatol Venereol 2014; 28: 1340-1343.

9- Ebrahim AA, Mustafa AI and El-Abd AM. Serum interlukin-17 as a novel biomarker in patients with acne vulgaris. J Cosmet Dermatol 2019; 1-5.

10- Dawson AL and Dellavalle RP. Acne vulgaris. BMJ 2013; 234: 346.

11- Topan AE, Savk E, Karaman G, et al. Assessment of the role of vitamin D and interleukin-17 in the pathogenesis of acne vulgaris. Turderm-Turk Arch Dermatol Venereology 2019; 53: 68-72.

12- Agak GW, Qin M, Nobe J, et al. Propionibacterium acnes induces an interleukin-17 response in acne vulgaris that is regulated by vitamin A and vitamin. D J Investig Dermatol 2014; 134(2): 366-373.

13- Kistowska M, Meier B, Proust T, et al. Propionibacterium acnes promotes Th17 and Th17/Th1 responses in acne patients. J Invest Dermatol 2015; 135(1): 110-118.

14- Murlistyarini S, Kumala Y, Megasasi Y, et al. Levels of IL-12, IL-17,and LL-37 in acne vulgaris. Turk J Immuno 2018; 6(2): 52-56.

15- Tan J, Kang S, Leyden J. Prevalence and risk factors of acne scarring among patients consulting dermatologists in the Unites States. J Drugs Dermatol 2017; 16: 97-102.

16- Rodero MP, Hodgson SS, Hollier B, et al. Reduced IL17A expression distinguishes a Ly 6c (lo) MHCII( hi) macrophage population promoting wound healing. J Invest Dermatol 2013; 133: 783-792.