Expression of Stress-associated Endoplasmic Reticulum Protein 1 (SERP1) in Patients with Vitiligo

Saad, Hala Ahmed; El- Rifaie, Abd-El Aziz Ahmed; Rashed, Laila Ahmed; Abdellatif, Mona Elsayed Ahmed

doi:10.21608/ejmr.2022.153132.1256

Expression of Stress-associated Endoplasmic Reticulum Protein 1 (SERP1) in Patients with Vitiligo

Document Type : Original Article

Authors

¹ Dermatology, Venereology and Andrology department, Faculty of Medicine, Beni-Suef University, Egypt

² Medical Biochemistry and Molecular Biology department, Faculty of Medicine, Cairo University, Egypt

10.21608/ejmr.2022.153132.1256

Abstract

Vitiligo stands out as one of the most common pigmentary skin disorders. This condition is marked by the presence of localized depigmented macules or patches, which arise due to the loss of melanocytes. The expression of stress-associated endoplasmic reticulum protein 1 (SERP1), also known as ribosome-associated membrane protein 4 (RAMP4), increased in response to stress that led to the buildup of unfolded proteins during endoplasmic reticulum (ER) stress. The aim of this study is to determine the relationship between SERP1 and the causes of vitiligo through real-time qPCR analysis. SERP1 was detected in a cohort of 30 vitiligo patients and 30 healthy controls using real-time quantitative polymerase chain reaction (qPCR). The expression of SERP1 in tissue showed a significant increase in Vitiligo skin lesions when compared to healthy skin samples from controls. SERP1 plays a role in the development of vitiligo.

Keywords

Main Subjects

Internal medicine ·

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