Measurment of Serum level of Catestatin in patients with Acne vulgaris

Document Type : Original Article

Authors

1 Dermatology department, Faculty of Medicine, Beni-Suef University, Beni-Suef 62511, Egypt

2 Biochemistry department, Faculty of Medicine, Beni-Suef University, Beni-Suef 62511, Egypt

3 Dermatology department, Sheikh Zayed Specialized Hospital, Giza12511, Egypt

Abstract

Background: Acne is a persistent inflammatory condition of the pilosebaceous unit. The pathogenesis encompasses three components: hyperseborrhea, aberrant follicular keratinization, and the development of Propionibacterium acnes inside the pilosebaceous unit. Objective: To evaluate serum catestatin (CST) level in Acne vulgaris patients as an attempt to answer the question about its role in disease pathogenesis and severity.  Patients and Methods: This case-control study was carried out on 45 patients with different degrees of acne vulgaris severity (Group A) in addition to 45 age and sex matched healthy volunteers as a control group (Group B).  For all participants, thorough history taking and good general and dermatological examination were done. Serum levels of catestatin were tested. Results: The present investigation revealed that CST levels (ng/ml) in acne vulgaris patients were reported at (8.21±5.70 ng/ml), but in healthy controls, they were (3.04±0.84 ng/ml). A very substantial difference existed between the two groups. Serum levels of CST were somewhat elevated in females relative to men; however, this disparity was statistically insignificant. The levels of CST were elevated in individuals with severe lesions; nevertheless, the serum levels of CST exhibited a non-statistically significant difference concerning lesion severity. There was a significant negative correlation between CST level (ng/ml) and age (years) of the acne patients (r=-0.321, p=0.032). Conclusion: A very substantial difference existed between the two groups regarding CST level but connection to acne severity was not verified.

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References

  1.  

    1. Dréno, B., Pécastaings, S., Corvec, S., Veraldi, S., Khammari, A., & Roques, C. (2018). Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: a brief look at the latest updates. Journal of the European Academy of Dermatology and Venereology, 32, 5-14.
    2. Alanazi, M. S., Hammad, S. M., & Mohamed, A. E (2018): Prevalence and psychological impact of Acne vulgaris among female secondary school students in Arar city. Electronic physician.; 10(8): 7224–7229.
    3. Bagatin, E., Freitas, T. H. P., Rivitti-Machado, M. C., Machado, M. C. R., Ribeiro, B. M., Nunes, S., & Rocha, M. A. D. D (2019): Adult female acne: a guide to clinical practice. Anais brasileiros de dermatologia.; 94(1): 62–75.
    4. González-Mondragón, E. A., Ganoza-Granados, L. D. C., Toledo-Bahena, M. E., Valencia-Herrera, A. M., Duarte-Abdala, M. R., Camargo-Sánchez, K. A., & Mena-Cedillos, C. A. (2022). Acne and diet: a review of pathogenic mechanisms. Boletín médico del Hospital Infantil de México, 79(2), 83-90.
    5. Yang, J., Yang, H., Xu, A., & He, L (2020): A Review of Advancement on Influencing Factors of Acne: An Emphasis on Environment Characteristics. Frontiers in public health.; 8, 450.
    6. Aung, G., Niyonsaba, F., Ushio, H., Kajiwara, N., Saito, H., Ikeda, S., Ogawa, H., & Okumura, K (2011): Catestatin, a neuroendocrine antimicrobial peptide, induces human mast cell migration, degranulation and production of cytokines and chemokines. Immunology.; 132(4): 527– 539.
    7. Deng, Z., & Xu, C (2017): Role of the neuroendocrine antimicrobial peptide catestatin in innate immunity and pain. Acta biochimica et biophysica Sinica.; 49(11): 967–972.
    8. Dréno B (2017): what is new in the pathophysiology of acne, an overview. Journal of the European Academy of Dermatology and Venereology.; 31 Suppl 5, 8–12.
    9. Ali Awad, E. Y., Soliman, F. E. S., & Maklad, S. A. (2022). The Effect of Acne Vulgaris on Body Image Satisfaction, Self Esteem and Quality of Life of Adolescents at Tanta city. Tanta Scientific Nursing Journal, 27(4), 188-206.
    10. El-Tahlawi, S. M., Mohamed, N. E., Mohamed, S. R., & Abd El Nasser, L. (2020). Serum level of vitamin D &Beta-2-defensin in patients with acne vulgaris. Fayoum University Medical Journal, 7(1), 134-146.
    11. Yücesoy, S. N., Ak, T., Öner, S., & Serdaroğlu, S. (2023). Serum catestatin levels in patients with acne vulgaris: single-center prospective study. Skin Appendage Disorders, 1-7.
    12. Durai, P. C. T., & Nair, D. G. (2015). Acne vulgaris and quality of life among young adults in South India. Indian journal of dermatology, 60(1), 33-40.
    13. George, R. M., & Sridharan, R. (2018). Factors aggravating or precipitating acne in Indian adults: a hospital-based study of 110 cases. Indian journal of dermatology, 63(4), 328-331.
    14. Jaber, R. M., Alnshash, B. M., Mousa, S. N., Fayoumi, H. S., Al-Qaderi, L. M., & Zant, A. M. (2020). The epidemiology of acne vulgaris among adolescents and young adults in Jordan University Hospital. Open Journal of Nursing, 10(4), 353-366.
    15. Shah, N., Shukla, R., Chaudhari, P., Patil, S., Patil, A., Nadkarni, N., & Goldust, M. (2021). Prevalence of acne vulgaris and its clinico‐epidemiological pattern in adult patients: Results of a prospective, observational study.Journal of cosmetic dermatology, 20(11), 3672-3678.
    16. Skroza N, Tolino E, Mambrin A, Zuber S, Balduzzi V, Marchesiello A, Bernardini N, Proietti I and Potenza C (2018). Adult acne versus adolescent acne. J Clin Aesthet Dermatol. 11:21–25.
    17. Al-Kubaisy, W., Abdullah, N. N., Kahn, S. M., & Zia, M. (2014). Sociodemographic characteristics of acne among university students in Damascus, Syria. Epidemiology Research International, 2014(1), 974019.
    18. Smithard, A., Glazebrook, C., & Williams, H. C. (2001). Acne prevalence, knowledge about acne and psychological morbidity in mid‐adolescence: a community‐based study.British Journal of Dermatology, 145(2), 274-279.
    19. Ogé, L. K., Broussard, A., & Marshall, M. D. (2019). Acne vulgaris: diagnosis and treatment. American family physician, 100(8), 475-484.
    20. Özçelik, S., Kulaç, İ., Yazıcı, M., & Öcal, E. (2018). Distribution of childhood skin diseases according to age and gender, a single institution experience. Turkish Archives of Pediatrics/Türk Pediatri Arşivi, 53(2), 105.‏
    21. Poli, F., Dreno, B., & Verschoore, M. (2001). An epidemiological study of acne in female adults: results of a survey conducted in France. Journal of the European Academy of Dermatology and Venereology, 15(6), 541-545.
    22. Nagy, I., Pivarcsi, A., Koreck, A., Széll, M., Urbán, E., & Kemény, L. (2005). Distinct strains of Propionibacterium acnes induce selective human β-defensin-2 and interleukin-8 expression in human keratinocytes through toll-like receptors. Journal of Investigative Dermatology, 124(5), 931-938.
    23. Nagy, I., Pivarcsi, A., Kis, K., Koreck, A., Bodai, L., McDowell, A., ... & Kemény, L. (2006). Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/chemokines in human sebocytes. Microbes and infection, 8(8), 2195-2205.
    24. Rokowska-Waluch, A., Pawlaczyk, M., Cybulski, M., Żurawski, J., Kaczmarek, M., Michalak, M., & Mojs, E. (2016). Stressful events and serum concentration of substance P in acne patients. Annals of dermatology, 28(4), 464-469.
    25. Nagiub, H., Elbayomi, Y., Mansour, M., & Zohdy, M. (2021). Serum level of the neuropeptide substance ‘P’in patients with acne vulgaris. Egyptian Journal of Dermatology and Venerology, 41(1), 10.‏
    26. El-Ramly, A. Z., Fawzi, M. M., Mahmoud, S. B., Ghaffar, M. M. A., & Shaker, O. G. (2016). Assessment of serum levels of cathelicidin and vitamin D in acne vulgaris. Journal of the Egyptian Women’s Dermatologic Society, 13(2), 99-105.
    27. Al‐Sudany, N. K., Mohammed, N. H., & Alrifai, S. B. (2019). Downregulation of S100a7a antimicrobial peptide in acne vulgaris patients after isotretinoin therapy. Dermatologic Therapy, 32(6), e13136.
    28. Borovaya, A., Dombrowski, Y., Zwicker, S., Olisova, O., Ruzicka, T., Wolf, R., ... & Sárdy, M. (2014). Isotretinoin therapy changes the expression of antimicrobial peptides in acne vulgaris. Archives of dermatological research, 306, 689-700.‏
    29. Chronnell, C. M., Ghali, L. R., Quinn, A. G., Bull, J. J., McKay, I. A., Philpott, M. P., ... & Cunliffe, W. J. (2001). Human β defensin-1 and-2 expression in human pilosebaceous units: upregulation in acne vulgaris lesions. Journal of Investigative Dermatology, 117(5), 1120-1125.‏
    30. Coates, S. J., Lee, E. H., & Granstein, R. D. (2017). Cutaneous Neuroimmunology. Clinical and Basic Immunodermatology, 179-199.
    31. Jati, S., Mahata, S., Das, S., Chatterjee, S., & Mahata, S. K. (2023). Catestatin: antimicrobial functions and potential therapeutics. Pharmaceutics, 15(5), 1550.
    32. Egger, M., Beer, A. G., Theurl, M., Schgoer, W., Hotter, B., Tatarczyk, T., ... & Kirchmair, R. (2008). Monocyte migration: a novel effect and signaling pathways of catestatin. European journal of pharmacology, 598(1-3), 104-111.‏
    33. Simac, P., Perkovic, D., Bozic, I., Matijas, M., Gugo, K., Martinovic, D., & Bozic, J. (2022). Serum catestatin levels in patients with rheumatoid arthritis. Scientific Reports, 12(1), 3812.‏
    34. Muntjewerff, E. M., Tang, K., Lutter, L., Christoffersson, G., Nicolasen, M. J., Gao, H., ... & Mahata, S. K. (2021). Chromogranin A regulates gut permeability via the antagonistic actions of its proteolytic peptides. Acta Physiologica, 232(2), e13655.‏
    35. Rabbi, M. F., Munyaka, P. M., Eissa, N., Metz-Boutigue, M. H., Khafipour, E., & Ghia, J. E. (2017). Human catestatin alters gut microbiota composition in mice. Frontiers in Microbiology, 7, 2151.
    36. Luketin, M., Mizdrak, M., Boric-Skaro, D., Martinovic, D., Tokic, D., Vilovic, M., ... & Bozic, J. (2021). Plasma catestatin levels and advanced glycation end products in patients on hemodialysis. Biomolecules, 11(3), 456.‏
    37. Ma, L. Y., Chen, W. W., Gao, R. L., Liu, L. S., Zhu, M. L., Wang, Y. J., ... & Hu, S. S. (2020). China cardiovascular diseases report 2018: an updated summary. Journal of geriatric cardiology: JGC, 17(1), 1.‏

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