Evaluation Of The Reproductive Toxicity Of Olanzapine And The Possible Protective Effect Of Vitamin E On Male Albino Rats

Document Type : Original Article

Authors

1 Pharmacology department, Faculty of Medicine, Beni-Suef University, Egypt

2 Pharmacology department, Faculty of Medicine, Cairo University, Egypt

3 Biochemistry department, Faculty of Medicine, Beni-Suef University, Egypt

Abstract

Atypical antipsychotics like olanzapine (OLZ) are standard treatments for schizophrenia and bipolar disorder. Atypical antipsychotics, or OLZ, have been associated with toxicity to the male reproductive system and sexual dysfunction over the long run. This study aims to examine the potential adverse effects of olanzapine on male albino rats' reproductive systems and possible preventive effect of vitamin E. The study included seven groups of ten adult male albino rats, one of which served as a control group that received nothing more than distilled water. For a duration of eight weeks, the remaining six groups of rats were given oral doses of OLZ (2.5, 5, or 10 mg/kg/d) or OLZ with vitamin E (200 mg/kg/d). We measured the testicles' and the body's mass in addition to sperm count and motility. As well serum levels of luteinizing hormone, follicle-stimulating hormone, and testosterone. Oxidative stress markers such as reduced glutathione (GSH), superoxide dismutase (SOD), and malondialdehyde (MDA) were evaluated in testicular tissue. Testicular tissue was examined histopathologically. The current investigation demonstrated that OLZ reduced sperm count and motility. It was shown that OLZ decreased blood levels of testosterone, FSH, and LH. While OLZ increased MDA levels, it also reduced the activities of SOD, CAT, and GSH in testicular tissue. Further examination using histopathology indicated that the seminiferous tubules had also deteriorated. These alterations were improved when vitamin E and OLZ were administered together. Conclusion: The male reproductive toxicity caused by OLZ seems to be mitigated by vitamin E.

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References

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