Comparison between Monofilament Threads and Platelet Rich Plasma in Treatment of Androgenetic Alopecia

Hassan, Mona Saied; El-Taweel, Abd-Elaziz Ibrahim; Gohary, Yasser Mostafa

doi:10.21608/ejmr.2025.328433.1716

Comparison between Monofilament Threads and Platelet Rich Plasma in Treatment of Androgenetic Alopecia

Document Type : Original Article

Authors

¹ M.B.B.Ch. The October 6 University, 2013

² Dermatology, Venereology and Andrology Faculty of Medicine, Benha University

³ Dermatology, Venerology and Andrology Faculty of Medicine, Beni-Suef University

10.21608/ejmr.2025.328433.1716

Abstract

Background: Androgenetic alopecia is a leading dermatology clinic complaint. Perceptions by others can have a major psychological impact on sufferers. The disease causes hair follicle shrinking. In this complex disease, androgens, genes, and environment contribute. Objectives: This study compares monofilament threads versus platelet-rich plasma intradermal injection for AGA therapy efficacy and safety. Method: in this randomized clinical trial, we enrolled 15 male and 15 female patients diagnosed androgenetic alopecia. Left and right sides of each patient's head were cleaned with 70% alcohol without local anesthesia. In three 30-day intervals, 0.2 mL·cm−2 interfollicular A-PRP injections were administered to the left side of the scalp at a depth of 5 mm, the patient received right-sided monofilament threads. Results: Male participants averaged 21–36 years old. Onset averaged 17–32 years old. All instances had positive family histories and progressive illness onset. PRP significantly increased hair density and diameter after intervention compared to monofilament. PRP considerably increased hair diameter and density more than monofilament. Sex had no significant effect on follow-up hair density, diameter, or percent increase in monofilament or PRP groups. After 3 months, PRP monofilament group patients' age and hair density correlated linearly negatively. Conclusion: In terms of facilitating hair repair, PRP and PDO seem to be a risk-free therapy with great promise. When comparing the two treatments, PRP dramatically improved hair density and thickness compared to PDO thread implantation.

Keywords

Main Subjects

Diagnostic

References

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