Serum ferritin and changes in pulmonary functions in Egyptian smokers

Document Type : Original Article

Authors

1 Chest diseases department, Faculty of Medicine, Beni-Suef University, Beni-Suef 62511, Egypt

2 Clinical and Chemical Pathology Department, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt

Abstract

Background: Ferritin is a crucial regulator of iron homeostasis and can contribute to oxidative tissue damage. Elevated ferritin levels may indicate inflammatory processes. Tobaccocan affect ferritin concentrations, potentially causing airway inflammation. High ferritin levels in smokers may be linked to emphysema and lung cancer. Objectives: This study aimed to investigate the possible relationship between serum ferritin and changes in pulmonary function in Egyptian cigarette smokers.  Methods: This Cross-sectional prospective study was conducted in Beni-Suef university hospital, department of chest diseases from September 2022 to March 2023.  Results: The study found significant positive correlations between ferritin levels, age, smoking years, daily cigarette consumption, height, BMI, Hb, and TLC. Conclusion: we identified significant positive correlations between Ferritin levels and Age, Smoking years, number of cigarettes per day, Smoking Index, BMI, Hb and TLC. In contrast, there were significant negative correlations between Ferritin and FEV1, FVC, FEV1/FVC ratio, FEF25-75, and SO2. Weight and Hct did not exhibit any significant correlations with Ferritin.

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References

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Egyptian Journal of Medical Research
Volume 6, Issue 3
July 2025
Pages 168-180

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