Histopathological Changes of Minimal Associated Pathological Lesions of Vocal Folds: Comparative Study between Smokers versus Non-smokers

Document Type : Original Article

Authors

1 Lecturer of Phoniatrics, ENT department Faculty of Medicine – Beni-Suef University, Egypt

2 Assistant Professor of Otorhinolaryngology, Faculty of Medicine, Beni-Suef University, Egypt.

3 Professor of Phoniatrics, ENT department, Faculty of medicine, Beni-suef University

4 Lecturer of pathology Faculty of medicine - Beni-Suef University.

5 M.B., B. Ch Faculty of medicine – Beni-suef university

6 Lecturer of Phoniatrics, ENT department Faculty of Medicine – Beni-Suef University

10.21608/ejmr.2025.328765.1718

Abstract

Objectives: Investigate the impact of cigarette smoking on the histopathology of resected minimal associated pathological lesions and compare it with the histopathology of the lesions of non-smoker patients for a better understanding of these changes, follow-up and proper management. Methods: There are two groups of 60 patients, (group A): 30 smokers and (group B): 30 non-smokers, they were selected from the outpatient clinic, Phoniatrics unit of Beni-Suef University Hospital both males and females, and both groups underwent micro-laryngeal surgery then histopathological examination for the resected lesions. Results: showed that smokers had a higher incidence of keratinization and dysplasia, as well as basement membrane changes in their lesions compared to non-smokers. Additionally, smokers had more hyaline degeneration. These findings suggest that cigarette smoke can have harmful effects on the epithelium and lamina propria of minimal associated pathological lesions. Conclusion: Cigarette smoking causes histologic alterations in the minimal associated pathological lesions, dysplasia, keratinization, and basement membrane changes, which were significantly higher in the smokers group.

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Main Subjects

References

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Egyptian Journal of Medical Research
Volume 6, Issue 3
July 2025
Pages 249-265

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