The Relation between Microvascular Complications of Type II Diabetes with Levels of Serum Progranulin.

Sheir, Rania El-Sayed; Salem, Mohamed Nabil; Mamdouh, Mohamed; AbdelKarem, Rehab Muhammad

doi:10.21608/ejmr.2020.89039

The Relation between Microvascular Complications of Type II Diabetes with Levels of Serum Progranulin.

Document Type : Original Article

Authors

¹ General internal medicine department, faculty of medicine, Beni-Suef University, Egypt

² General internal medicine department, faculty of medicine, Beni-Suef University, Egypt.

³ Clinical and Chemical Pathology department, Faculty of Medicine, Beni-Suef University, Egypt.

10.21608/ejmr.2020.89039

Abstract

This study elucidated for the first time that serum PGRN concentrations increased in Egyptian patients during the presence of several microvascular complications. PGRN is considered as a biomarker for diabetic microangiopathy and its severity and its serum level was increased due to close relation with the progress of diabetic microangiopathy. It is subsequently proved that PGRN level in diabetic patients who suffered from type II diabetes should be owing high solicitude for diagnosis and following up. These results fundamentals that PGRN level could be used as a potential therapeutic target for management.