Urinary Retinol Binding Protein (RBP) Level as an early Biomarker of Diabetic Nephropathy in type 2 Diabetic Patients

Abdallah, Nilly Helmy; Kamel, Mahmoud Farid; Abdelaziz, Abdelrahman; Abd Elkareem, Rehab Muhammad

doi:10.21608/ejmr.2020.90106

Urinary Retinol Binding Protein (RBP) Level as an early Biomarker of Diabetic Nephropathy in type 2 Diabetic Patients

Document Type : Original Article

Authors

¹ Internal Medicine department, Faculty of Medicine, Beni-Suef University, Egypt.

² Internal Medicine department, Faculty of Medicine, Beni-Suef University, Egypt

³ Clinical Pathology department, Faculty of Medicine, Beni-Suef University, Egypt.

10.21608/ejmr.2020.90106

Abstract

Background:Diabetes mellitus continues to be an important clinical problem throughout the world In 2014, 8.5% of adults aged 18 years and older had diabetes. In 2015, diabetes was the direct cause of 1.6 million deaths. Objectives:To investigate the role of retinol binding protein (RBP) in the early stage of diabetic nephropathy, in patients with type 2 diabetes mellitus (T2DM). Methods: This cross-sectional observational study recruited patients with longstanding T2DM and healthy control subjects. Patients with T2DM were further stratified based on their urine albumin–creatinine ratio (UACR). Urinary concentrations of RBP were determined using an enzyme-linked immunosorbent assay.

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